摘要
目的:总结Numb与上皮间质转化(epithelial mesenchymal transitions,EMT)的研究进展,并讨论Numb在EMT中的可能作用机制。方法:应用PubMed及CNKI期刊全文数据库检索系统以"Numb、肿瘤和EMT"等为关键词,检索1990-01-2012-10的相关文献。共检索到英文文献815篇,中文文献285篇。纳入标准:1)以肿瘤中的Numb与EMT的关系;2)Numb在上皮间质转化中的作用机制研究。根据纳入标准分析文献38篇。结果:Numb是参与肿瘤信号转导途径的重要成分,新的研究表明,Numb表达下调或缺失,EMT的发生加剧。作用机制可能是其通过影响肿瘤细胞E-钙黏蛋白的定位、调控Notch等信号通路在肿瘤EMT过程中起关键作用,研究发现,10%的癌组织中伴有Notch1基因变异。通过参与EMT而诱导肿瘤形成和发展可能为Numb影响肿瘤发生、发展的又一重要机制。结论:肿瘤中Numb的表达水平及其相关信号通路在EMT中可能起重要作用,但具体作用方式和机制仍未阐明。
OBJECTIVE：To sum the research progress Numb with epithelial mesenchymal transition,and discuss the possible role of Numb in the epithelial-mesenchymal transition mechanism. METHODS： Articles with numb and EMT as key words between 1990-01-2012-10 were retrieved in PubMed and CNKI databases. Inclusion criteria： 1） The relation- ship of numb and epithelial-mesenehymal transition; 2） The mechanism of numb in the epithelialmesenchymal transition. RESULTS： Numb is involved in an important component of the tumor signal transduction pathways, new research suggests Numb downregulated or missing,EMT occurrence exacerbated. There is gene variation of Notchl in 10% tumor tissues. The mechanism of action may affect the positioning of E-cadherin and regulate of Notch signaling pathway,that may play a critical role in tumor EMT process. Induced tumor formation and development through participation in EMT may be an- other important mechanism of Numb affecting cancer development. CONCLUSION： Numb expression level of the tumor and its associated signaling pathway may play an important role in epithelial-mesenchymal transition, but the specific mode of action and mechanisms not yet been elucidated, which needs further investigation.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第15期1203-1206,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(30973503
81071650
81050007)
教育部高等学校博士学科点专项科研基金(20092104110008)
辽宁省高等学校攀登学者计划(2009-2012)
辽宁省教育厅高等学校科研项目计划(LS2010175)
辽宁省科学技术计划项目(2011404013-3)
