摘要
目的 观察替米沙坦联合辛伐他汀治疗慢性充血性心力衰竭（CHF）的疗效.方法 将114例CHF患者随机分为替米沙坦＋辛伐他汀治疗组（联合治疗组）、辛伐他汀组和常规对照组,各组均38例,随访180 d,观察治疗前、后NYHA心功能分级,以超声心动图检测左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数（LVEF）及E/A,观察治疗效果.结果 联合治疗组总有效率92.1%,优于辛伐他汀组（78.9%）和常规对照组（65.8%）（P＜0.05）. LVEF、LVEDD改变辛伐他汀组优于常规对照组（P＜0.05）,与常规治疗组比较,联合治疗组LVEDD、LVESD、LVEF及E/A改变更加显著（P＜0.05）.结论 替米沙坦联合辛伐他汀治疗CHF比单用辛伐他汀的临床疗效更好.
Objective To observe the clinical therapeutic efficacy of the telmisartan combined with simvastatin in patients with congestive heart failure （CHF）. Methods The total 114 CHF patients were randomly divided into three groups ： routine treatment group, simvastatin treatment group and telmisartan＋simvastatin treatment group. The clinical therapeutic efficacy as well as LVEDD,LVESD,LVEF and E/A were analyzed before and 180 days after treatment. Results The total effect in telmisartan＋simvastatin treatment group （92.1%） was much high- er than in simvastatin treatment group（78.9% ） and routine treatment group（65.8% ） （P〈0.05）. In telmisartan＋sim- vastatin treatment group, LVEDD, LVESD, LVEFand E/A were proved much better than those in routine treatment group（P〈0.05 ）. Conclusion Combined administration of telmisartan and simvastatin exerts better effects on patients with CHF than a single administration of simvastatin.
出处
《中国心血管病研究》
CAS
2011年第2期115-117,共3页
Chinese Journal of Cardiovascular Research
