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厚朴酚对人小细胞肺癌H446细胞增殖的影响 被引量：1

Effects of magnolol on the proliferation of human small cell lung cancer cells H446
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摘要 目的:研究厚朴酚对H446细胞增殖和凋亡的影响。方法:MTT法测定厚朴酚对H446细胞的细胞毒作用。结果:厚朴酚可明显抑制H446细胞增殖,作用呈明显的时间和剂量依赖性。结论:厚朴酚可抑制H446细胞增殖。 Aim To study the effects of magnolol on the proliferation of human small cell lung cancer cells H446.Methods：Cell viability was detected by MTT assay.Results ：Magnolol inhibited H446 cells proliferaion in a concentration-and time-dependent manner.Conclusion：Magnolol inhibited the proliferation of H446 cells.
作者 董秀 韩兆峰 王晓波 王淳 蔡硕
机构地区 辽宁中医药大学基础医学院
出处 《中国民族民间医药》 2011年第5期31-31,共1页 Chinese Journal of Ethnomedicine and Ethnopharmacy
基金 辽宁省高等学校科研计划项目2008年度立项课题(项目编号:2008441)
关键词 厚朴酚 小细胞肺癌 细胞增殖 magnolol small cell lung cancer cells proliferation
分类号 R734.2 [医药卫生—肿瘤]
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参考文献5

  • 1清·黄爽(辑),神农本草经.北京:中医古籍出版社.1982:370.
  • 2王海曼,张淑文.厚朴酚药理作用的研究进展[J].北京中医药,2009,28(7):562-565. 被引量：16
  • 3Hsu, Y. F. , et al. , Involvement of Ras/Raf - 1/ERK actions in the magno-lolinduced upregulation, of p21 and cell - cycle arrest in colon cancer cells. MolCarcinog, 2007, 46 (4): 275-83..
  • 4Park, E. J. , et a]. , Protective effects of honokiol and magnolol on tertiarybutyl hydroperoxide - or D - galactosarnineinduced toxicity in rat primary hepato- cytes. Planta Med, 2003. 69 ( 1 ) : p. 33 -7.
  • 5Page N, ReadW, Tierney R, et al. The epidemiology of small cell lung car-cinoma [J]. Proc Am Soc Clin Oncol, 2002, 21 : 305A.

二级参考文献22

  • 1刘可云,黄贤珍.厚朴酚对大鼠局灶性脑缺血再灌注损伤的保护作用与γ-氨基丁酸的关系[J].时珍国医国药,2006,17(6):971-972. 被引量：7
  • 2Squires RF,Ai J, Witt M-R,et al.Honokiol and Magnolol Increase the Number of [3H]Muscimol Binding Sites Three-Fold in Rat Forebrain Membranes In Vitro Using a Filtration Assay, by Allosterically Increasing the Affinities of Low-Affinity Sites [J]. Neurochemical Research, 1999,24:1593-1602.
  • 3Tanaka K,Hasegawa J,Asamitsu K,et al. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor-KB[J].European Journal of Pharmacology, 2007,565:212-219.
  • 4Umezawa K, Chaicharoenpong C. Molecular design and biological activities of NF-kappaB inhibitors [J]. Mol Cells, 2002,14:163-167.
  • 5Li N,Song Y, Zhang WZ, et al. Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract[J].Regulatory Toxicology and Pharmacology, 2007,49:154- 159.
  • 6Saito J, Sakai Y, Nagase H. In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens [J]. Res, 2006,609:68-73.
  • 7Wang JP, Hsu MF, Raung SL, et al.Anti-inflammatory and analgesic effects of magnolol [J]. Naunyn-Schmiedeberg's Arch Pharmacol, 1992,346:707-712.
  • 8Wang JP,Raung SL,Chen CC,et al.The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators [J]. Naunyn-Schmiedeberg's Arch Pharmacol, 1993,348: 663-669.
  • 9Shih HC,Wei YH,Lee CH,et al. Magnolol alters cytokine response after hemorrhagic shock and increases survival in Subsequent intraabdominal sepsis in rats [J]. Shock, 2003,20:264-268.
  • 10Shih HC,Wei YH,Lee CH. Magnolol alters the course of endotoxin tolerance and provides early protection against endotoxin challenge following sublethal hemorrhage in rats [J].Shoek, 2004,22:358-363.

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中国民族民间医药
2011年 第5期

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