2型糖尿病并发脑梗死患者血管内皮标志物的变化及意义被引量：2

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摘要目的探讨2型糖尿病及并发脑梗死时血管内皮标志物的变化及临床意义。方法测定31例单纯2型糖尿病患者,33例2型糖尿病并发脑梗死患者和25例正常对照者血浆内皮素(ET-1)、血管性假性血友病因子(vWF)水平及血脂、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)。结果单纯糖尿病组及糖尿病并发脑梗死组血浆ET-1、vWF水平、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)高于正常对照组,糖尿病并发脑梗死组ET-1、vWF、TC、LDL-C高于单纯糖尿病组,差异统计学意义(P<0.01);相关分析显示,血浆ET-1、vWF水平与TC、LDL-C、HbAlc呈正相关。结论 2型糖尿病患者及并发脑梗死时有内皮损伤及内皮功能障碍,血浆ET-1、vWF水平升高;血浆内皮标志物ET-1、vWF-水平可反映2型糖尿病的内皮损伤情况,早期预测脑梗死的发生。

作者付艳芹辛雅萍张东铭张苏河

机构地区郑州大学第二附属医院内分泌科

出处《中国实用神经疾病杂志》 2011年第5期47-48,共2页 Chinese Journal of Practical Nervous Diseases

关键词 2型糖尿病脑梗死内皮素-1 血管性假性血友病因子

分类号 R587.1 [医药卫生—内分泌]

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