摘要
目的:探讨2型糖尿病并发脑梗死患者血清肝细胞生长因子(HGF)的水平及临床意义。方法:采用双抗体酶联免疫吸附法(ELISA)测定30例2型糖尿病并发脑梗死患者(A组)急性期(入院第2天)、恢复期(发病第40天)和30例无脑梗死的2型糖尿病患者(B组)、30例健康体检者(C组)的血清HGF浓度。结果:各组血清HGF浓度比较,A组急性期明显高于B组(t=5.05,P<0.01)和C组(t=8.81,P<0.01),B组亦高于C组(t= 2.41,P<0.05),但A组恢复期与C组比较差异无统计学意义(t=1.97,P>0.05)。结论:HGF作为神经营养因子参与了2型糖尿病并发脑梗死后脑损伤的修复。
Objective： To investigate serum levels of Hepatocyte growth factor （HGF） and its clinical significance in type 2 diabetic patients with cerebral infarction. Methods： The serum levels of HGF in 30 patients with type 2 diabetes mellitus and acute cerebral infarction （group A）, 30 patients with type 2 diabetic patients without cerebral infarction （group B） and 30 healthy persons were examined. Results： The levels of HGF in the patients in group A were significantly higher than those in group B （P〈0.01） and in group C（P〈0.01）. The levels of HGF in group B were obviously higher than those in group C （P〈0.05）, but without obvious difference between group A in recovery phase and group C（P〉0.05）. Conclusion： HGF is related to the pathogenesis of strokes and may reflect the severity of atherosclerosis of type 2 diabetic patients with cerebral infarction.
出处
《神经损伤与功能重建》
2007年第6期352-354,共3页
Neural Injury and Functional Reconstruction
关键词
脑梗死
2型糖尿病
肝细胞生长因子
cerebral infarction
type 2 diabetes mellitus
hepatocyte growth factor
