摘要
目的探讨无创通气在治疗阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)合并高血压病中的作用,并通过随访了解无创通气在本类病例中对心脑血管疾病的预防作用。方法 92例患者均确诊为高血压病,同时行多导睡眠仪(PSG)监测均诊断为阻塞性睡眠呼吸暂停综合征(OSAS)。将92例患者随机分成A组(即无创通气治疗组,共48例)及B组(即非无创通气治疗组,共44例),两组患者均予以安慰剂治疗1个月,A组患者同时予以无创通气治疗,B组不予无创通气治疗;1个月后两组患者均根据血压情况继续调整降压药至达标,同时对两组患者进行5年随访,观察心脑血管事件的发生情况。结果 A组降压效果显著好于B组,B组心脑血管事件的发生率显著高于A组。结论对于阻塞性睡眠呼吸暂停综合征合并高血压病的患者通过无创通气的配合治疗,可以更好地控制血压,同时可减少心脑血管事件的发生。
Objective To study the effect of noninvasive ventilation in treatment of obstructive sleep apnea syndrome（OSAS） with hypertension,and evaluate the clinical value of noninvasive ventilation to prevent cardiovascular and cerebrovascular events in same file by follow-up visit.Methods Totally 92 patients were diagnosed hypertension,and OSAS by polysomnography（PSG） monitoring.Meanwhile all patients were randomly divided into group A（48 cases） and group B（44 cases）,Patients of group A were treated with placebo for 1 month acompany noninvasive ventilation.Patients of group B were treated with placebo only.Both groups adjusted depressor according to blood pressure till compliance after 1 month,did a follow-up visit for 5 years to observe the occurrence of cardiovascular and cerebrovascular events.Results Antihypertensive effect of group A was significantly better than group B,The incidence of cardiovascular and cerebrovascular events in group A was significantly lower than group B.Conclusion It can control the blood pressure better and reduce cardiovascular and cerebrovascular events to use depressor with noninvasive ventilation therapy for OSAS patients with hypertension.
出处
《医药论坛杂志》
2010年第22期84-86,共3页
Journal of Medical Forum
