摘要
目的:了解当前本院临床分离肺炎链球菌的血清型/群分布及耐药趋势,为临床合理使用抗生素提供参考。方法:以2004～2009年临床分离的822株肺炎链球菌为研究对象,采用荚膜肿胀试验进行血清分型/群,E-test检测菌种对青霉素、头孢呋辛、头孢地尼、头孢克罗、红霉素、四环素、左氧氟沙星、万古霉素等8种抗生素的敏感性。结果:2004年青霉素不敏感肺炎链球菌(PNSP)的分离率为49.4%,并呈逐年上升趋势,至2006年PNSP分离率高达67.8%,2009年下降至51.0%。822株肺炎链球菌最常见的型/群是19群,其次是23、6、14、3、其他。PNSP在6种血清型/群中所占的比例在2004～2009年期间无显著性变化(P>0.05)。肺炎链球菌对其他β内酰胺类抗生素的非敏感趋势类似青霉素,对红霉素、四环素的非敏感率始终在60%以上,其中青霉素耐药肺炎链球菌(PRSP)对红霉素和四环素几乎100%耐药,对左氧氟沙星、万古霉素的非敏感率均<3%。结论:临床分离肺炎链球菌以19群、23群、6群、14群、3群常见;对β内酰胺类抗生素的非敏感率自2007年呈下降趋势,且对左氧氟沙星、万古霉素始终具有较高的敏感性。
Objective：To investigate serotype/serogroup distribution and the trend of antimicrobial resistance of Streptococcus pneumoniae isolated from patients hospitalized for pneumonia in our hospital,so as to provide guidance for rational clical treatment.Methods：822 strains of S.pneumoniae were collected from 2004 to 2009.Minimal inhibition concentrations（MIC） of penicillin,cefuroxime,cefdinir,cefaclor,erythromycin,tetracycline,levofloxacin,vancomycin were determined by E-test.And the isolates were serotyped with the quellung reaction.Results：The prevalence of PCG-nonsusceptible S.pneumoniae（PNSP） isolates increased gradually from 49.4% in 2004,reaching a statistical peak in 2006（67.8%）,then decreasing to 51.0% in 2009.Among 822 strains of S.pneumoniae,the most prevalent serogroups/serotypes were type 19,23,6,14,3,others.The distribution of 6 serotypes in PNSP isolates was not statistically different between years（P0.05）.The prevalence of S.pneumoniae isolates nonsusceptible to other β-lactam antibiotics,similar to penicillin.The prevalence of strains nonsusceptible to erythromycin and tetracycline were consistently60%.Almostly all PCG-resistant S.pneumoniae（PRSP） were resistant to both erythromycin and tetracycline throughout the period.The prevalence of strains resistant to levofloxacin and vancomycin were 3% over the period.Conclusion：Serotype/serogroup 19,23,6,14,3 are the commom types among the S.pneumoniae.Decreased prevalence of β-lactam resistant strains has been occurring since 2007.And These S.pneumoniae strains are highly sensitive to levofloxacin and vancomycin consistantly.
出处
《中国当代医药》
2011年第8期9-11,共3页
China Modern Medicine
关键词
肺炎链球菌
血清型/群
耐药性
抗生素
Streptococcus pneumoniae
Serotype/serogroup
Antimicrobial resistance
Antibiotics
