糖尿病肾病的发病机制及治疗被引量：11

Pathogenesis and treatment of diabetic nephropathy

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摘要糖尿病肾病（DN）的发病机制未完全明了，近年来发现DN的发病与炎性反应、缓激肽减少、足细胞损伤及microRNA等有关。由于DN的发病机制复杂，尚缺乏特效治疗，目前主张除控制蛋白摄入及优化血糖控制外，肾素-血管紧张素-醛固酮系统阻断剂、他汀类药物、螺内酯及霉酚酸酯也显示了一定的肾脏保护作用。 The pathogenesis of diabetic nephropathy （DN） remains obscure. Recent studies show that the patbogenesis of DN involves in inflammatory mechanisms, reduction of bradykinin,injury of podocytes and microRNA. Because of the complex patbogenesis of DN,there is no specific therapy. Besides the controlling of dietary protein intake and blood glucose, renin-angiotensin-aldosterone system blocker, statins, spironolactone, mycophenolate mofetil also show some protective effects of kidney.

作者刘艳春刘佳

机构地区南京医科大学第一附属医院肾内科

出处《国际内分泌代谢杂志》 2011年第2期84-86,共3页 International Journal of Endocrinology and Metabolism

关键词糖尿病肾病炎症足细胞肾素-血管紧张素-醛固酮系统 Diabetic nephropathy Inflammation Podocyte Renin-augiotensin-aldosterone system

分类号 R587.2 [医药卫生—内分泌]

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参考文献15

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