摘要
细胞外基质成分Ⅳ型胶原、ｌａｍｉｎｉｎ和ｆｉｂｒｏｎｅｃｔｉｎ是微血管基膜的主要成分。１０例死于脑室内出血（ＩＶＨ）的早产儿和１０例死于非脑室出血的早产儿，每例均取侧脑室壁和脉络丛两份标本。用抗Ⅳ型胶原、ｌａｍｉｎｉｎ和ｆｉｂｒｏｎｅｃｔｉｎ的抗体标记。侧脑室周围抗体的阳性产物多呈不连续线状。在ＩＶＨ组中３种细胞外基质成分阳性产物的平均单位面积比非ＩＶＨ组小，Ｐ＜０．０１。脑室内出血组Ⅳ型胶原、ｌａｍｉｎｉｎ和ｆｉｂｒｏｎｅｃｔｉｎ的阳性产物呈不连续线状的微血管总数比非脑室内出血组的多，而阳性产物呈连续线状的微血管总数比非脑室内出血组的少。这表明ＩＶＨ组中３种细胞外基质成分比非ＩＶＨ组少，这也是早产儿室管膜下和脉络丛微血管未成熟的特征，是早产儿易患ＩＶＨ的形态学基础之一。
Extracellular matrixsuch as type Ⅳ collagen,laminin,and fibronectin are significant compositions of basement membrane.Specimens of total 20 cases which were taken from lateral ventricular walls and choroid plexus in 10 preterm neonates died of intraventricular hemorrhage and other 10 preterm neonates died of nonintraventricular hemorrhage,were marked with antibodies against type Ⅳ collagen,laminin,and fibronectin,and their positive staining around microvessels.Average appearance of positive products of these three extracellular matrix in TVH group showed less than that in nonIVH group (P<0.05).That choroid plexus and subependymal microvessels of preterm neonates were shot of type IV collagen,laminin,and fibronectin may be accounted for premature basement membrane of microvessels and occurrence of IVH cases.
出处
《中国优生与遗传杂志》
1999年第4期59-60,共2页
Chinese Journal of Birth Health & Heredity
基金
福建省自然科学基金
关键词
细胞外基质
脑室内出血
早产儿
Extracellular matrix,Intraventricular hemorrhage,Preterm neonate. (Original article on page 59)
