摘要
目的观察并比较丹参注射液及丹参素钠对小鼠的急性毒性,初步探讨丹参注射液毒性作用机制及毒效成分。方法 40只小鼠随机分为4组,所用药量均含丹参素(0.28 g/kg)。其中丹参素钠2组,分别腹腔或静脉给药;丹参注射液2组,给药方法同前。观察各组小鼠死亡情况,并取脏器做病理,比较两药毒性。结果给药后丹参素钠组无死亡;静脉注射丹参注射液组全部死亡,腹腔注射丹参注射液组死亡率为50%,其病理检查发现肝、肾、肺、肠等脏器充血或出血。结论丹参素钠可能不是丹参注射液的主要毒效成分。丹参注射液过量可致死亡,不可滥用。
Objective To observe and compare the acute toxicity of Salvia miltiorrhiza injection and sodium danshensu in mice,and to explore the mechanism and toxic components of Salvia miltiorrhiza injection.Methods Forty mice were randomized into 4 groups.The mice received an intravenous or intraperitoneal infusion of sodium danshensu or Salvia miltiorrhiza injection（equal to Danshensu 0.28 g/kg）in 4 groups,respectively.Mortality of mice in each group was recorded,then visceral organs were taken out for pathological examination.And the toxicities of two injections were compared.Results No mice died in sodium danshensu group,while all mice died in the group with intravenous injection of Salvia miltiorrhiza injection,and 50% of mice died in the group with intraperitoneal injection of Salvia miltiorrhiza injection.Bleeding or congestion was observed in organs like liver,kidney,intestine and lung by pathological examination.Conclusion Sodium danshensu may be not the main toxic component in Salvia miltiorrhiza injection.Overdose of Salvia miltiorrhiza injection might cause death.
出处
《山西医科大学学报》
CAS
2011年第3期191-193,共3页
Journal of Shanxi Medical University
基金
安徽省高校自然科学研究基金资助项目(KJ2008B084)
关键词
丹参注射液
丹参素钠
急性毒性
sodium danshensu
Salvia miltiorrhiza injection
acute toxicity
