摘要
目的:观察帕罗西汀合并小剂量奎硫平治疗强迫症的临床疗效和不良反应。方法:将符合入组条件的80例强迫症患者随机分为两组,研究组服用帕罗西汀和奎硫平治疗,对照组单用帕罗西汀治疗,共观察8周,于治疗前,治疗后1、2、4、6、8周末应用Y-BOCS、HAMD、HAMA量表评定疗效,不良反应量表(TESS)记录治疗过程中的不良反应,并随访1年,观察其1年内的复发率。结果:两组治疗后Y-BOCS、HAMD、HAMA评分均明显下降(P<0.05),Y-BOCS、HAMA在第6、8周末的评分显示两组间有明显差异(P<0.05);8周末研究组有效率为83.78%,高于对照组的有效率72.97%(P<0.05);两组不良反应评分及1年内的复发率比较无明显差异(P>0.05)。结论:帕罗西汀联合小剂量奎硫平治疗强迫症起效快,可提高疗效,并能迅速改善睡眠障碍和焦虑症状,不会明显增加不良反应,对复发率无明显影响。
Objective：To study the clinical effect of paroxetine with small-dose quetiapine in the treatment of obsessive-compulsive disorder.Methods：80 hospitalized patients who met the criteria of CCMD-3 for obsessive-compulsive disorder were assigned to study group and control group,study group were given paroxetine combining quetiapine control group given paroxetine only for the treatment of 8 weeks.The efficacy and side effects were evaluated with Y-BOCS、HAMD、HAMA and TESS at the end of 1nd、2th、4th、6th and 8th.The relapse of one year was observed by follow up.Results：After treatment,scores of Y-BOCS、HAMD and HAMA of both groups were significantly lower than pre-treatment（P0.05）.There were significant differences in the scores of Y-BOCS and HAMA between two groups at the end of 6th and 8th（P0.05）.The effective rate of study group（83.78%）were higher than control group（72.97%,P0.05）.There were no significantly difference in TESS and the relapse of one year between two groups（P0.05）.Conclusion：Paroxetine with small-dose quetiapine could improve the efficacy compared with paroxetine in the treatment of obsessive-compulsive disorder,and could improve sleep orexis and the feeling discomfort.But quetiapine had no distinct effect no relapse.
关键词
帕罗西汀
奎硫平
强迫症
Paroxetine
Quetiapine
Obsessive-compulsive disorder
