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利培酮合并氟西汀治疗强迫症疗效分析 被引量:5

A comparative analysis of risperidone combining with fluoxetine in the treatment of obsessive-compulsive disorder
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摘要 目的 :探讨利培酮合并氟西汀治疗强迫症的疗效。 方法 :将符合条件的 39例强迫症患者随机分为利培酮合并氟西汀组和氟西汀组 ,治疗 8周。采用强迫症量表 (Y BOCS)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表 (HAMD)评定疗效。 结果 :治疗结束时两组Y BOCS、HAMD、HAMA的评分均显著降低 ,更以合用组明显。 结论 Objective:The purpose of this study is to investigate the efficacy of risperidone combining with fluoxetine in the treatment of obsessive compulsive disorder (OCD). Method:39 patients with OCD were randomly treated with risperidone combining with fluoxetine ( n =20) and fluoxetine only( n =19).The efficacy was measured with Yale Brown obsessive compulsive scale (Y BOCS),Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD). Results:There were significant differences between two groups in overall response showed by the reduction rate of Y BOCS,HAMA and HAMD total scores. Conclusion:It is suggested that risperidone combining with fluoxetine have a superior effectiveness in the treatment of OCD.
机构地区 天津市安定医院
出处 《临床精神医学杂志》 2003年第4期213-214,共2页 Journal of Clinical Psychiatry
关键词 利培酮 氟西汀 强迫症 Risperdone Fluoxetine Obsessive compulsive disorder
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参考文献3

  • 1Erzegovesi S,Cavallini MC,Cavedini P,et al. Clinical predictors of drug response in obsessive-compulsive disorder.J Clin Psychopharmacol,2001,21:488
  • 2McDougle CJ,Epperson CN,Pelton GH,et al.A double-blind,placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder.Arch Gen Psychiatry,2000,57:794
  • 3Ravizza L,Barzega G,Bellino S,et al.Therapeutic effect and safety of adjunctive risperidone in refractory obsessive-compulsive disorder (OCD).Psychopharmacol Bull,1996,32:677

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