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氧化应激在类风湿关节炎中的表现 被引量:6

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摘要 当机体的氧化作用与抗氧化作用失衡并向氧化作用倾斜时,机体产生氧化应激(oxidative stress)。氧化应激可促进活性氧簇(reactive oxygen species,ROS)和活性氮簇(reactive nitrogen species,RNS)等的产生[1]。产生的活性氧簇和活性氮簇不仅损伤核酸、蛋白质、脂质等生物分子以及线粒体等细胞器,还作为信使分子参与调节基因表达等生理病理过程,进而对细胞或机体组织产生损伤。
作者 韦超 常晓天
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第2期127-130,共4页 Chinese Journal of Rheumatology
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  • 1Tuteja N,Singh MB,Misra MK,et al.Molecular mechanisms of DNA damage and repair:progress in plants.Crit Rev Biochem Mol Biol,2001,36:337-397.
  • 2Hitchon CA,El-Gabalawy HS.Oxidation in rheumatoid arthritis.Arthritis Res Ther,2004,6:265-278.
  • 3Ramasamy R,Vannucci SJ,Yan SS,et al.Advanced glycation end products and RAGE:a common thread in aging,diabetes,neurodegeneration,and inflammation.Glycobiology,2005,15:16R-28R.
  • 4Steenvoorden MM,Toes RE,Ronday HK,et al.RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro.Clin Exp Rheumatol,2007,25:740-742.
  • 5Filippin LI,Vercelino R,Marroni NP,et al.Redox signalling and the inflammatory response in rheumatoid arthritis.Clin Exp Immunol,2008,152:415-422.
  • 6Corda S,Laplace C,Vicaut E,et al.Rapid reactive oxygenspecies production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide.Am J Respir Cell Mol Biol,2001,24:762-768.
  • 7Migita K,Honda S,Yamasaki S,et al.Regulation of rheumatoid synovial cell growth by ceramide.Biochem Biophys Res Commun,2000,269:70-75.
  • 8Misra MK,Sarwat M,Bhakuni P,et al.Oxidative stress and ischemic myocardial syndromes.Med Sci Monit,2009,15:209-219.
  • 9Lee YH,Choi SJ,Kim A,et al.Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium.J Korean Med Sci,2000,15:88-92.
  • 10Gheorghe KR,Korotkova M,Catrina AI,et al.Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.Arthritis Res Ther,2009,11:R83.

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