摘要
目的比较注射用苦参素纳米球(KU-PLGA-NS)与注射用苦参素普通粉针剂(KUI)在大鼠体内的药动学特性。方法建立HPLC法检测大鼠血浆中苦参素,采用ANOVA法选择房室模型,将所测得的血药浓度-时间数据,采用DAS程序进行分析,根据F值与AIC选择房室模型求算药动学参数。结果等剂量KU-PLGA-NS和KUI的AUC0-t分别为(785.57±170.92)、(342.43±54.49)mg·L-1.min,Cmax为(18.51±2.47)、(28.48±5.40)mg/L,t1/2Ke为(91.69±1.94)、(11.51±2.47)min。结论 KU-PLGA-NS在大鼠体内的药动学特性与KUI比较AUC和Cmax增加,t1/2延长。
Objective To compare the in vivo pharmacokinetic properties of Kushenin Injection Nanoparticles（KU-PLGA-NS） with the ordinary Kushenin Injection（KUI） of rats.Methods A method has been developed and validated for the quantification of kushenin in rat plasma.Using ANOVA method to choose the compartment model,The plasma concentration-time data were measured and then analyzed by DAS program on the computer.According to F values,the AIC choice compartment model pharmacokinetic parameters were calculated.Results The main pharmacokinetic parameters of KU-PLGA-NS and KUI were as follows： AUC0-t were（785.57 ± 170.92） and（342.43 ± 54.49） mg.L？1.min,respeticevly;Cmax were（18.51 ± 2.47） and（28.48 ± 5.40） mg/L,respeticevly;t1/2Ke were（91.69 ± 1.94） and（11.51 ± 2.47） min,respeticevly.Conclusion Comparison of in vivo pharmacokinetic characteristics of rats between KU-PLGA-NS and KUI has a significant change with AUC and Cmax increase and t1/2 extension
出处
《中草药》
CAS
CSCD
北大核心
2011年第3期526-529,共4页
Chinese Traditional and Herbal Drugs
基金
安徽省自然科学基金项目(070413117)
安徽医科大学校级研究项目(2008kj12)
国家中医药管理局中医药科研三级实验室"中药药理实验室"项目(TCM-2009-197)
关键词
苦参素
纳米球
药动学
血药浓度
房室模型
kushenin
nanoparticles
pharmacokinetics
blood drug concentration
compartment model
