摘要
[目的] 探讨抗抑郁药物帕罗西汀在胃肠功能紊乱治疗中的作用.[方法] 将80例已确诊的胃肠功能紊乱患者随机分为两组,对照组应用常规内科治疗（抑酸和促胃动力药）,观察组应用上述常规内科治疗加抗抑郁药物帕罗西汀,治疗8周.以汉密尔顿抑郁量表、汉密尔顿焦虑量表、胃肠功能紊乱症状评定量表的减分率评定疗效,并比较两组的不良反应.[结果] 治疗组和观察组的三个量表评分随治疗时间的延长逐渐降低,治疗前后三个量表评分有显著性差异.观察组的减分率明显高于对照组,差异有显著性（P〈0.05）.两组均无严重不良反应.[结论] 帕罗西汀在胃肠功能紊乱的常规治疗基础上有增效作用,能显著改善患者的躯体不适症状.
[Objective] To explore the role of antidepressants（paroxetine） in the treatment of gastrointestinal dysfunction. [Methods] Eighty patients diagnosed as gastrointestinal dysfunction were divided into two groups. The control group received routine medical treatment with acid inhibitor and gastric mobility agent. The treatment group received above routine medical treatment and paroxetine. They were treated for 8 weeks. The efficacy was assessed by Hamilton＇s depression scale（HAMD）, Hamilton＇s anxiety scale（HAMA） and gastrointestinal dysfunction symptom rating scale（FGIDSR）. [Results] The scores of three scales in treatment group and control group decreased gradually with the lasting of the time of therapy. There were significant differences in the scores of three scales between before and after treatment. The decreasing of the scores in treatment group was obviously higher than that in control group, and there was significant difference between two groups. [Conclusion] Paroxetine based on the conventional therapy for the treatment of gastrointestinal dysfunction has synergistic effect, and can noticeably improve the somatic unwell symptoms of patients.
出处
《医学临床研究》
CAS
2011年第2期233-235,共3页
Journal of Clinical Research
