摘要
目的观察N-末端B型利钠肽原(NT-proBNP)在脓毒症及其脓毒症合并心肌损伤患者的水平变化。方法武汉大学人民医院住院的脓毒症患者37例,其中并心肌损伤者17例(A组),非心肌损伤者20例(B组),健康对照者20例(C组)。测定入院后24 h内血浆NT-proBNP水平及肌钙蛋白I的水平,对比各组之间血浆NT-proBNP水平,并将NT-proBNP水平与肌钙蛋白I进行相关性分析。结果 A、B、C组NT-proBNP水平入院后分别为(3180.6±1420.57)pg/ml,(746.66±225.63)pg/ml,(60.195±28.305)pg/ml。对比各组入院后NT-proBNP的水平,有统计学意义(P<0、01)。且脓毒症并心肌损伤组肌钙蛋白I为3.8822±1.8221 ng/ml,与NT-proBNP成正相关。结论 NT-proBNP在脓毒症患者血浆中水平升高,且在心肌损伤组与非心肌损伤组中有差异,血浆NT-proBNP与肌钙蛋白I成正相关,两者升高越明显病情越危重,可作为判断心肌是否受损的指标。
Objective To observe the variation of NT-proBNP level in patients with sepsis and sepsis combined with myocardial injury.And search for the early diagnostic index of myocardial injury.MethodsWe recruited 37 patients received a diagnosis of sepsis according to the diagnosis and treatment program of septicemia in 2003 by the American College of Chest Physicians and the Society of Critical Care Medicine（ACCP/SCCM）.The 37 cases were divided into myocardial injury group（group A） and non-myocardial injury group（group B）.Meanwhile,twenty non-sepsis patients were enrolled as control group（group C）.We measured NT-proBNP in plasma in these 57 patients and then analyzed the differences of its level among the 3 groups.Meanwhile,the results were compaired to troponin I in group A.ResultsThere were significant differences among NT-proBNP levels in plasma of the 3 groups：（3180.6±1420.57）pg/ml in group A,（746.66±225.63）pg/ml in group B,and（60.195±28.305）pg/ml in group C（P0.01）.ConclusionThe level of NT-proBNP in plasma is significant higher in patients with sepsis.And the levels are different in sepsis combined with myocardial and sepsis without myocardial.The concentration of NT-proBNP and CTnI were significantly positively correlated,it can be used as the laboratory marker for detection of myocardial functional lesion.
出处
《临床肺科杂志》
2011年第4期523-524,共2页
Journal of Clinical Pulmonary Medicine
