摘要
煤焦沥青(CTP)依次用甲醇、环乙烷和苯提取,被分为M、C及B三个组份。这些组份又分别被分为M_1及M_2、C_1及C_2、B_1及B_2六个亚组份。各组份及亚组份都进行了诱发大鼠肺癌试验,每头动物的气管注射量为每周1次,每次2mg,共10周。各组份及亚组份中的BaP及常见PAH含量用HPLC法作了测定。20个月后的肺癌发生率为:M12.5％、M_120％、M_210％、C92％、C_10％、C_277％、B26％、B_147％、B_22％。用同一剂量的BaP诱发的肺癌率为27％。各组份及亚组份的致肺癌能力与其中的BaP和PAH含量无任何关系。研究表明,BaP及常见PAH不是CTP中对诱发肺癌起主要作用的致癌成份。CTP中的致肺癌物绝大部分存在在C组份及C_2亚组份中,它们可能是一组至今尚未被认识的新致癌物。
Coal tar pitch(CTP)was successively extracted by methanol, cyclohexane and benzene and divided into 3 fractions, M, C and B. These fractions were then subdivided into M1 and M2, C1 and C1, B1 and B2, respectively. The lung carcinogenicity assay for all the fractions/subfractions were studied in Wistar rats. The intratracheal instillation dosage for each rat was 2 mg once a week for 10 weeks. The BaP and other common PAH of each fraction/subfraction were determined by HPLC method. The lung cancer incidence induced by the fraction/subfraction after 20 months were: M, 12.5%; M1, 20% M2, 10% C, 92% C1, 0% C2, 11%; B, 26% B1, 47% B2, 2%. The lung cancer incidence by BaP at the same dose level was 27%. No correlation was found between the BaP/PAH content and the lung carcinogenic potency among the fractions/subfractions. It has proved that BaP or other common PAH are not the major carcinogenic components responsible for luna carciaogenicity in CTP. The strong lung cancer-inducing compounds are mostly existed in the C fraction and C2 subfraction of CTP, they are probably a group of new cartinogens, not yet recognized by us at the present time.
出处
《工业卫生与职业病》
CAS
CSCD
1989年第6期321-325,共5页
Industrial Health and Occupational Diseases
关键词
煤焦沥青
肺肿瘤
致癌物
coal tarpitch
eyclohexane soluble fraction
benzo (a) pyrene
polycyclic aromatic hydrocarbons
lung carcinogens
