摘要
目的 探讨 Ｎ Ｇ硝基 Ｌ精氨酸（ Ｌ Ｎ Ｎ Ａ） 对沙土鼠海马区ｃ Ｇ Ｍ Ｐ 合成的影响。方法 钳夹沙土鼠的双侧颈总动脉制造脑缺血模型，应用免疫荧光法染色。结果 Ｌ Ｎ Ｎ Ａ 能抑制海马区ｃ Ｇ Ｍ Ｐ 的合成。结论 Ｌ Ｎ Ｎ Ａ 是一氧化氮合酶强有力的抑制剂，从而抑制了 Ｎ Ｏ 的产生及其介导的ｃ Ｇ Ｍ
AIM To observe the influence of L NNA on hippocampal cGMP production after recirculation following ischemia. METHODS Both vessels occlusion and immunofluorescent methods in gerbil hippocampal tissue slices incubated in vitro were used. RESULTS Recirculation following ischemia leads to a rise in hippocampal cGMP concentration. cGMP positive cells mainly distributed in rediatum layer and molecullar in the CA 1 subfield, L NNA decreased cGMP synthesis. L NNA was a strong NOS inhibitor. CONCLUSION The role of endogenous NO mediating cGMP synthesis is inhibited by L NNA.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第4期349-350,共2页
Chinese Pharmacological Bulletin
基金
山东省自然科学基金
