摘要
本研究使用石墨炉原子吸收法测定了矽肺大鼠不同病变肺组织中的铝含量,并观察了给予柠檬酸铝后的影响。结果表明,矽肺组动物肺中铝含量高于正常对照组。给予柠铝后,铝能迅速到达肺部并维持较高浓度。矽肺组的肺结节组织铝浓度(μgAl/g干肺)低于非结节组织,而柠铝治疗组则相反.提示正常体内铝量少,不能拮抗大量进入体内石英的毒性;给铝剂后则可提高体内抗石英的需铝量。矽肺组织内的石英有聚集铝的趋势,因此,体内石英和铝的相互作用关系值得进一步探讨.
Aluminium(Al) in the lungs of silicotic rats treated with Al-citrate was measured by graphite furnance atomic absorption spectrometry. Al content in the lungs of silicotic rats was higher than the normal rats.After Al treatment, the Al content became much higher and maintained in higher lever. In contrast to Al-treated rats, in silicotic rats-the Al content (μg Al/g dry tissue) in the silicotic parts of the lungs was lower than in the non-silicotic parts. The results suggest that quartz in the lungs seems to hare the capability of attracting Al to accumulate in silicotic tissue. Since the minute amount of Al in normal rat can not play its role well in anti-quartz toxicityt the Al pretreatment can supply the demand for Al. Thus the correlation between quartz and Al in vivo is worthy to be further studied.
出处
《工业卫生与职业病》
CAS
CSCD
1989年第3期134-138,共5页
Industrial Health and Occupational Diseases
关键词
矽肺
铝
silicosis
aluminium
silicosis treatment
