摘要
目的研究血清抗C1q抗体水平与狼疮肾炎(lupus nephritis,LN)病理类型及活动性的相关性。方法酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测47例系统性红斑狼疮(systemlupus erythematosus,SLE)患者(狼疮肾炎37例,非狼疮肾炎10例)血清抗C1q抗体水平,并与狼疮肾炎病理类型及活动性指标进行相关性分析。结果 SLE患者血清抗C1q抗体水平(92±55)U/ml,较正常对照组显著升高;LN患者(99±56)U/ml高于非LN患者(64±53)U/ml(t=3.185,P<0.01)。各肾脏病理类型的血清抗C1q抗体水平有统计学差异,IV型LN患者(126±48)U/ml,高于其他各LN病理分型(P<0.01)。血清抗C1q抗体水平与肾脏病理病变活动指数呈正相关(r=0.750,P<0.01)。肾炎复发组血清抗C1q抗体水平(131±54)U/ml在各临床活动度分组中最高(P<0.01)。结论血清抗C1q抗体水平与SLE患者肾脏损害显著相关,监测其变化可为临床评估治疗提供重要依据。
Objective To analyze the correlation of serum anti-C1q antibody level with renal pathological characteristic and nephritis activity in patients with lupus nephritis （LN）. Methods Serum anti-C1q antibodies were examined by enzyme-linked immunosorbant assay （ELISA） in 47 patients with system lupus erythematosus （SLE） including 37 LN patients and 10 non-LN patients. The correlation between anti-C1q antibody level and renal pathohistology and lupus nephritis activity were analyzed. Results Serum level of anti-C1q antibody in SLE patients [（92±55） U/ml] was significantly higher than that of control groups, and higher in LN patients [（99±56） U/ml] than non-LN patients [（64±53） U/ml] （P0.01）. The serum levels of anti-C1q antibody of each renal pathohistology class were significantly different, and of class IV was the highest [（126±48） U/ml, P0.01]. The serum level of anti-C1q antibody was positively correlated with activity index of renal pathohistology （r=0.750,P0.01）.The serum level of anti-C1q antibody of nephritic flare group [（131±54） U/ml] was highest in all clinical activity classes. Conclusion The serum level of anti-C1q antibody are significantly correlated with renal lesion. Measurement of the antibody may contribute to the evaluation and therapy of LN.
出处
《华南国防医学杂志》
CAS
2011年第1期35-37,共3页
Military Medical Journal of South China
关键词
抗C1Q抗体
狼疮肾炎
肾脏病理
活动指数
Anti-C1q antibody
Lupus nephritis
Renal pathohistology
Activity index
