摘要
目的:探讨抗C1q抗体在狼疮肾炎(LN)患者血清中的表达及其临床意义。方法:使用ELISA法对46例LN患者血清进行检测,并与31例无肾炎临床表现的系统性红斑狼疮(SLE)患者作对照。结果:LN患者血清中抗C1q抗体浓度显著高于对照组(P<0.01)。LN患者中抗C1q抗体有较高的阳性率,与对照组比较有显著性差异(P<0.01)。结论:在LN患者中,存在着抗C1q抗体的高表达。抗C1q抗体在LN发病中起重要的作用,在LN诊断和判定其活动性方面有重要作用。
Objective ：To explore the expression of anti-Clq antibodies and clinical significance in patients with lupus nephritis（LN）. Methods：ELISA assay was performed to examine anti-C1q antibodies in the sera of 46 patients with LN and 31 patients of systemic lupus erythematosus without renal damage. Standard methods were used for laboratory testing. Results：Anti-C1q antibodies were sianificantly higher in LN than in controls（P〈〈0.01）. The positive rate of anti-C1q antibodies was significantly higher in LN than in controls. There was significant and positive correlation anti-C1q antibodies and SLEDAI score in LN（P〈0. 01）. Concluslon：In patients with LN,anti-C1qantibodies were significantly higher than control groups. And anti-C1q antibodies was suggested to play a crucial role in the patients of LN. Anti-C1q antibodies had potential utility as a diagnostic tool and disease activity marker.
出处
《临床医药实践》
2005年第11期818-819,共2页
Proceeding of Clinical Medicine
