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局部黏着斑激酶作为肿瘤治疗靶点的研究进展 被引量：3

Focal adhesion kinase,a novel target for cancer therapy
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摘要 局部黏着斑激酶(focal adhesion kinase,FAK)是一种非受体型酪氨酸蛋白激酶,是细胞内重要的骨架蛋白与多种信号通路的关键分子。FAK在肿瘤发生、发展、迁移和侵袭的各个阶段都具有重要作用,FAK已经被当作潜在的肿瘤治疗靶点来研究。该综述将对FAK与肿瘤的关系以及FAK作为肿瘤治疗靶点的研究进展进行探讨。 Focal adhesion kinase（FAK）,a cytoplasmic non-receptor protein tyrosine kinase,serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways.FAK is involved in tumor cell survival,proliferation,migration and metastasis.Currently,FAK has been regarded as a potential target for cancer therapy.This review is to summarize the relationship between FAK and tumor progression,and to discuss the strategies targeting FAK for cancer treatment.
作者 张文静 黄启来 华子春
机构地区 澳门科技大学中医药学院和澳门药物及健康应用研究所 南京大学医药生物技术国家重点实验室
出处 《生命科学》 CSCD 北大核心 2011年第1期7-12,共6页 Chinese Bulletin of Life Sciences
基金 澳门科技发展基金(071/2009/A3 091/2009/A)
关键词 局部黏着斑激酶 抗肿瘤 治疗 focal adhesion kinase antitumor treatment
分类号 Q26 [生物学—细胞生物学] R730.54 [医药卫生—肿瘤]
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参考文献45

  • 1Hao H, Naomoto Y, Bao X, et al. Focal adhesion kinase as potential target for cancer therapy (Review). Oncol Rep, 2009, 22 (5): 973-9.
  • 2van Nimwegen MJ, van de Water B. Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol, 2007, 73 (5): 597-609.
  • 3Lim ST, Mikolon D, Stupack DO, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7 (15): 2306-14.
  • 4Harte MT, Hildebrand JD, Burnham MR, et al. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J Biol Chem, 1996, 271 (23): 13649-55.
  • 5Liu Y, Loijens JC, Martin KH, et al. The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell, 2002, 13 (6): 2147-56.
  • 6Taylor JM, Hildebrand JD, Mack CP, et al. Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase. J Biol Chem, 1998, 273 (14): 8063-70.
  • 7Brown MC, Perrotta JA, Turner CE. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol, 1996, 135 (4): 1109-23.
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同被引文献42

  • 1谭余良,殷勤伟.RNAi在癌症治疗中的应用[J].药学学报,2005,40(3):193-198. 被引量：7
  • 2Maung K,Easty DJ,Hill SP,et al.Requirement for focal adhesion kinase in tumor cell adhesion.Oncogene,1999,18 (48):6824-6828.
  • 3Golubovskaya VM,Kweh FA,Cance WG.Focal adhesion kinase and cancer,Histol Histopathol,2009,24(4):503-510.
  • 4Vang J,Pan WH,Clawson GA,et al.Systemic targeting inhibitor of kappa B kinasc inhibits melanoma tumor growth.Cancer Rcs,2007,67(7):3127-3134.
  • 5Chan KT,Cortesio CL,Huttenlocher A.FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.Cell Biol,2009,185 (2):357-70.
  • 6Le Y,Xu L,Fang J,et al.FAK silencing inhibits leukemogenesis in BCR /ABL2 transformed hematopoietic cells.Am J Hematology,2009,84 (5):273-278.
  • 7Luo M,Fan H,Nagy T,et al.Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Cancer Res,2009,69(2):466-474.
  • 8Halder J,Kamat AA,Landen CN,et al.Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.Clin Cancer Res 2006,12(3):4916-4924.
  • 9Hanks SK, Pohe TR, Signaling through focal adhesion kinase [ J].Bioessays, 1997, 19 (2) : 137-145.
  • 10Shieh JM, Cheng TH, Shi MD, et al. A-tomatine suppresses invasion and migration of human non-small cell lung cancer NCI-H460 cells through inactivating FAK/PI3K/Akt signaling pathway and reducing binding activity of NF-jB [ J]. Cell Biochem Biophys, 2011, 60( 1 ) : 297-310.

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生命科学
2011年 第1期

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