摘要
目的:探讨海洛因成瘾者在静息状态下脑功能连接与正常对照的区别。方法:对16例海洛因成瘾者和16例匹配的正常对照进行静息状态下的脑功能扫描。选择杏仁核为种子区,比较两组之间脑功能连接的区别。结果:同正常对照相比,海洛因成瘾者杏仁核与左右扣带回、左右扣带回前部以及右侧Brodmann 24脑区功能连接下降。结论:这种功能连接的下降可能反映出海洛因成瘾者的杏仁核功能处于脱抑制状态,造成海洛因成瘾者犒赏、动机、记忆功能异常,从而参与了海洛因成瘾行为产生和维持。
Objective：To study the differents in brain functional connectivity between heroin dependent patients and normal controls at conscious resting state.Methods：Using fMRI,we investigated the brain functional connecticity in 16 heroin-dependented patients and 16 matched normal controls.We selected the amaygdala as seed.Results：Compared with controls,the heroin addicts had significant（P〈0.005） decreased brain functional connectivity between amygdala and some brain regions,including bilateral cingulate gyrus,bilateral anterior cingulate and right brodmann area 24.Conclusion：This study shows that there are abnormal functional connectivity in heroin dependent patients.These functional deficiencies may be correlated with occurrence and maintenance of addiction behaviors.
出处
《中国临床心理学杂志》
CSSCI
CSCD
2011年第1期7-9,共3页
Chinese Journal of Clinical Psychology
基金
国家重点基础研究发展973计划(2009CB522000)
国家自然科学基金(30971050)
教育部博士点基金新教师项目(78720070533068)资助
