摘要
目的探索难治性抑郁症(TRD)患者脑静息状态默认网络与正常对照组间的差异。方法10例TRD患者和12名对照者接受440 s的静息脑功能扫描。运用功能连接分析得出个体的静息状态默认网络并进行组间比较。结果与对照组比较,TRD组双侧颞中回、直回、楔前回、左侧眶回、右侧顶下小叶与后扣带回的连接功能减弱。结论TRD患者的静息默认网络连接中多个脑区活动减弱,可能导致患者自我控制和情感行为功能异常。
Objective To explore the difference of resting-state default-mode network functional connectivity in patients with treatment-resistant depression（TRD） and in healthy subjects.Methods Ten patients with TRD and 12 healthy control subjects underwent 440 s fMRI scans while resting quietly.Functional connectivity analysis was used to isolate the default mode network in each subject.Group maps of the default-mode network were generated and compared between the two groups.A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on network functional connectivity.Results Functional connectivity of both side of middle temporal gyrus,rectal gyrus,precuneus gray matter,left orbital gyrus,right inferior parietal lobule,and post cingulate gyrus in TRD group weakened compared with that of the control subjects.Conclusion There are resting default network connection weakening in multiple brain areas in TRD patients,which may lead to self-control and emotional behavior abnormal in patients.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第12期2182-2185,共4页
Chinese Journal of Medical Imaging Technology
基金
上海交通大学医学院重点学科项目
上海市重点学科建设项目(S30203)
关键词
抑郁症
默认网络
功能连接
扣带回后部
Depression
Default-mode network
Functional connectivity
Posterior cingulate cortex
