摘要
目的:以流化床包衣法制备含阿魏酸的川芎效应组分(ACC)的缓释微丸。方法:采用挤出-滚圆法制备ACC速释微丸,以阿魏酸的体外释放度为考察指标,优化ACC缓释微丸的包衣液处方,并评价该缓释微丸的粉体学性质和缓释效果。结果:ACC缓释微丸圆整度好,在12 h内体外缓慢释药,尤特奇(Eudragit RS 100)的用量是影响微丸释药的主要因素。结论:制备的ACC缓释微丸在体外达到较好的缓释效果。
Objective： To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed. Method： The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated. Result： The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release. Conclusion： The coating pellets show the obviously sustained-release effects.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第4期439-442,共4页
China Journal of Chinese Materia Medica
基金
上海市教育委员会科研创新项目(09YZ117)
上海市教育委员会重点学科项目(J50302)
关键词
川芎
缓释微丸
流化床
尤特奇
Ligusticun chuanxiong
sustained-release pellet
fluid-bed
eudragit
