摘要
目的 探讨扁平疣患者抑郁情绪障碍与细胞免疫功能的关系.方法 采用自评抑郁量表（SDS）对68例扁平疣患者抑郁情绪进行评定,并比较分析有无抑郁的扁平疣患者外周血单一核细胞产生白介素-2（IL-2）的能力和天然杀伤（NK）细胞活性.结果 扁平疣患者的SDS标准分显著高于全国常模[（46.08±12.76）分vs（41.88±10.57）分;t=3.71,P＜0.01],差异有统计学意义.抑郁障碍的发生率为38%（26例）.扁平疣患者中未婚者SDS标准分（48.89±11.52）分,抑郁发生率29%（20例）,已婚者SDS标准分（43.16±10.17）分,抑郁发生率9%（6例）,差异有统计学意义（t=2.28,x2=4.86,P＜0.05）.女性患者SDS标准分（49.01±11.36）分,男性（41.96±10.48）分,差异有统计学意义（t=2.21,P＜0.05）.具有抑郁情绪障碍者外周血单一核细胞产生IL-2的能力、NK细胞活性分别为（46.64±12.28）×10^3U/L、（19.23±5.60）%,低于无抑郁情绪患者[（56.15±18.32）×10^3 U/L、（24.65±6.89）%,t=3.18、3.32,P＜0.01].结论 部分扁平疣患者存在明显的抑郁情绪障碍,且抑郁者多伴有细胞免疫功能异常.
Abstract：Objective To evaluate the possible association between depression and cellular immunologic status in patients with verruca planea. Methods Depression was assessed with the Self-rating Depression Scale （SDS）, and the inteleukin-2 （IL-2）produced by peripheral blood mononuclear cells （PBMC） and the activity of natural killer （NK） cells were measured in 68 patients with verruca planea. Results The SDS scores in patients with verruca planea（46. 08 ± 12.76） were significantly higher than those in the controls（41.88 ± 10. 57, t = 3.71, P 〈 0. 01 ）, and 38% of the patients were affected by depression. The mean scores of depression （48.89 ± 11. 52 ） and the rate （ 29% ） of depressive disorder among patients unmarried （single） were significantly higher than those married [（43. 16 ± 10. 17 ）, 9%;t = 2. 28, x2 = 4. 86, P 〈 0. 05] . The mean scores of depression among female patients （49. 01 ± 11.36 ）were significantly higher than male patients [（41.96 ± 10.48 ） ,t =2. 21 ,P 〈0. 05] . In patients affected by depression, the level of the IL-2[（46. 64 ± 12. 28） × 103 U/L] produced by PBMC and the activity of NK cells[（ 19. 23 ±5.60）%] were significantly decreased than those in undepressive group[（56. 15 ± 18. 32） ×103 U/L, （24.65 ± 6. 89）%; t = 3.18, 3. 32, P 〈 0.01] . The differences above were all significant. Conclusions Patients with vermca planea are partly affected by depression and the cellular immunologic status may be abnormal among the patients with depression.
ZANG Yun-shu ,SUN Xiu-fang, WANG Qing-hong.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2011年第1期7-9,共3页
Chinese Journal of Psychiatry
关键词
抑郁症
白细胞介素类
杀伤细胞
天然
疣
Depressive disorder
Interleukins
Natural killer cells
Warts
