摘要
泛肽（Ｕｂｉｑｕｉｔｉｎ，简称Ｕｂ）是一个由７６个氨基酸残基组成的非常保守的小蛋白质。泛肽依赖性的蛋白质降解途径（Ｕｂｉｑｕｉｔｉｎ＿ｄｅｐｅｎｄｅｎｔｐｒｏｔｅｏｌｙｔｉｃｐａｔｈｗａｙ）是目前已知的最重要的、有高度选择性的蛋白质降解途径。泛肽系统由Ｕｂ、Ｕｂ活化酶、Ｕｂ结合酶、Ｕｂ＿蛋白质连接酶、Ｕｂ＿Ｃ末端水解酶和２６Ｓ蛋白酶体组成。本文详细地介绍了泛肽系统各个组成部分的种类、结构与功能，蛋白质泛肽化及其降解机制和底物识别模式。
Ubiquitin (Ub) is a conserved small protein consisted of 76 amino acid residues. Ubiquitin_dependent proteolytic pathway is the most important selective proteolytic pathway. Ubiquitin system is composed of ubiquitin, ubiquitin_activating enzymes, Ubiquitin_conjugating enzymes, ubiquitin_protein ligases, ubiquitin_C_terminal hydrolase and 26S proteasomes. This review discussed and described components of ubiquitin system, structure and function of each component, machanisms of protein ubiquitination and degradation of ubiquitinated proteins, and modes of recognition of substrates.
出处
《植物学通报》
CSCD
1999年第3期208-218,共11页
Chinese Bulletin of Botany
基金
国家自然科学基金
关键词
泛肽
泛肽系统
蛋白质泛肽化
蛋白质降解
Ubiquitin, Ubiquitin system, Protein ubiquitination, Protein degradation
