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PAMAM-Poloxamer的合成及作为药物载体的体外试验 被引量：5

Synthesis of PAMAM-Poloxamer Dendrimers and in Vitro Test as a Drug Carrier
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摘要 合成新型树状大分子聚酰胺胺-泊洛沙姆(PAMAM-Poloxamer),考察其作为药物载体的可行性。将泊洛沙姆188一端羟基以硫酸二甲酯甲基化,另一端羟基经过对硝基苯基氯甲酸酯活化,与PAMAM G2.0连接,目标产物PAMAM-Poloxamer用FT-IR、1HNMR进行结构表征。MTT研究其细胞毒性。通过体外增溶实验研究该药物载体对难溶抗癌药物喜树碱的增溶作用,以及pH对增溶作用的影响;通过光敏性试验研究其对喜树碱光敏性的稳定能力。通过上述方法成功合成树枝状大分子PAMAM-Poloxamer,其细胞毒性与PAMAM相比有所降低;对喜树碱有较好的增溶作用;对喜树碱光不稳定性具有很好的稳定作用。树枝状大分子PAMAM-Poloxamer有望成为一种新型药物载体材料。 Polymeric drug delivery systems were used to improve the aqueous solubility and photostability of Camptothecin（CPT）.PAMAM-Poloxamer dendrimers were synthesized and characterized by FT-IR and 1HNMR.Their cytotoxicity was investigated by MTT assay.The potential of PAMAM-Poloxamer dendrimers as drug carriers of CPT was researched.The results showed that PAMAM-Poloxamer dendrimers exhibite lower toxicity in comparison with PAMAM,and could increase the solubility and photostability of CPT.These studies indicated that PAMAM-Poloxamer dendrimers might be considered as a new drug carrier.
作者 马丽芳 郑云 杜翔宇 王晰婷 郭丽
机构地区 四川大学化工学院 四川大学华西药学院
出处 《四川大学学报（工程科学版）》 EI CAS CSCD 北大核心 2011年第1期190-194,共5页 Journal of Sichuan University (Engineering Science Edition)
关键词 聚酰胺胺-泊洛沙姆树状大分子 合成 细胞毒性 药物载体 PAMAM-Poloxamer dendrimers synthesis MTT drug carrier
分类号 R944.9 [医药卫生—药剂学]
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参考文献15

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二级参考文献5

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共引文献6

同被引文献85

引证文献5

二级引证文献11

四川大学学报（工程科学版）
2011年 第1期

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