摘要
采用生物活性因子拼接法将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮中,合成了11个新型不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经1H NMR,IR和元素分析表征。初步生物活性测试结果表明,部分化合物具有一定的抗黄瓜花叶病毒(CMV)活性。
Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound.Eleven novel oxime-esters of curcumin derivatives were synthesized.The structures were characterized by 1H NMR,IR and element analysis.The preliminary bioassay showed that some of them exhibited a certain inhibitory activity of anti-CMV.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第1期36-40,77,共6页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20662004)
贵州大学研究生创新基金资助项目(2010022)
关键词
姜黄素
肟酯
合成
抗病毒活性
curcumin
oxime ester
synthesis
anti-CMV activities
