摘要
对26例胶质瘤和18例颅内良性病变患者行18F-FDG和11C-MET PET/CT颅脑显像,定性和半定量分析两种显像图像。结果显示:11C-MET和18F-FDG PET/CT对胶质瘤诊断的准确率分别为88.6%和65.9%。半定量分析,26例胶质瘤11C-MET摄取值比值T/NGmax显著高于18F-FDG的T/NGmax(1.95±0.52 vs 0.90±0.27,t=9.101,P<0.001)。11C-MET和18F-FDG对高级别胶质瘤诊断的灵敏度无显著差异(100%vs.64.3%;χ2=3.20,P>0.05);对低级别胶质瘤诊断的灵敏度11C-MET(83.3%)高于18F-FDG(33.3%,χ2=4.16,P<0.05)。11C-MET显像高级别胶质瘤T/NGmax(2.07±0.51)与低级别胶质瘤(1.81±0.52)无显著差异(t=1.302,P=0.205);18F-FDG显像高级别胶质瘤T/NGmax(1.03±0.30)高于低级别胶质瘤(0.75±0.11,t=3.198,P=0.004)。表明11C-MET PET/CT显像对胶质瘤的诊断,特别是对低级别胶质瘤检出优于18F-FDG,两种显像综合应用有利于胶质瘤的准确分级。
In this paper, we investigate the diagnostic value of 11C-methionine （MET） positron emission tomography/computed tomography （PET/CT） for brain gliomas, and compare the results to lSF-fluorodeoxyglucose. Forty-four patients with suspected gliomas were examined with 11C-MET and 18F-FDG PET/CT. 18F-FDG and 11C-MET PET/CT images were compared and evaluated by visual and semiquantitative analysis. The accuracy of 11C-MET and 18F-FDG PET/CT for detecting gliomas were 88.6% and 65.9%, respectively. Semiquantitative analysis showed that the 26 gliomas had higher mean ±SD T/NGmax ratio on 11C-MET PET/CT than on 18F-FDG PET/CT （1.95±0.52 vs. 0.90±0.27, t=9.101, P〈0.001）. IIC-MET had a higher sensitivity than 18F-FDG （83.3% vs. 33.3%, χ2=4.16, P〈0.05） for low-grade gliomas, but it did not differ significantly from 18F-FDG in the sensitivity for high-grade gliomas （100% vs. 64.3%, χ2=3.20, P〉0.05）. The difference was no significant, too, between high- and low-grade gliomas, compared by ^11C-MET T/NQmax ratio （2.07±0.51 vs. 1.81±0.52, t= 1.302, P=0.205）. 18F-FDG T/NGmax ratio in high-grade gliomas was significantly higher than that in low-grade gliomas （1.03±0.30 vs. 0.75±0.11, t= 3.198, P=0.004）. It is concluded that l lC-MET PET/CT is more accurate than 18F-FDG PET/CT for detecting and delineating gliomas, especially for low-grade gliomas, and it can play a complement role to 18F-FDG in tumor grading.
出处
《核技术》
CAS
CSCD
北大核心
2011年第2期151-155,共5页
Nuclear Techniques
基金
国家自然科学基金(30370426
30870731)资助
