摘要
目的:观察氟伐他汀对急性冠脉综合征(ACS)患者血清白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs-CRP)水平的影响,探讨其对心血管事件发生率的影响。方法:134例ACS患者被随机分成氟伐他汀干预组和常规治疗组,同时设置健康对照组;检测ACS两组治疗前、治疗后2周IL-18、TNF-α、hs-CRP水平变化,观察心血管事件发生情况。结果:ACS组治疗前与对照组比较血清IL-18、TNF-α及hs-CRP水平明显升高,治疗后常规治疗组与氟伐他汀干预组IL-18、TNF-α及hs-CRP均较治疗前降低(P<0.05),氟伐他汀干预组降低更明显(P<0.01);且随访期间发生死亡、心衰、心绞痛、心肌梗死也明显少于常规治疗组(P<0.05)。结论:氟伐他汀可以降低ACS患者血清炎症因子水平,抑制炎症反应,从而减少心血管事件的发生。
Objective:To investigate the effects of fluvastatin on levels of interleukin-18(IL-18),tumor necrosis factor-α(TNF-α),high-sensitivity CRP(hs-CRP) and cardiovascular events in patients with acute coronary syndromes.Method:The study groups included 134 cases of acute coronary syndrome( ACS) patients,which randomly were divided into routine drugs and addititonal fluvastatin cases,and normal controls.Levels of IL-18,TNF-α,hs-CRP and cardiovascular events were measured before and after treatment.Results:IL-18,TNF-α and hs-CRP levels were significantly higher in patients with ACS before treatment than normal control group.Levels of IL-18,TNF-α and hs-CRP were decreased after treatment of fluvastatin and routine,but the group treated with fluvastatin decreased higher than the routine treat group,during observation the composite of cardiac death,recurrence of unstable angina,re-infarction reduced also.Conclusion:These results showed that inflammation was existent in ACS,fluvastatin could significantly depress inflammation and reduce cardiovascular events.
出处
《微循环学杂志》
2011年第1期44-46,I0002,共4页
Chinese Journal of Microcirculation
