摘要
目的:探讨血清胱抑素C(CysC)和尿白蛋白排泄率(UAER)联合检测,对高血压患者早期肾损害的诊断价值。方法:测定320例确诊原发性高血压患者内生肌酐清除率(Ccr)并据此分为肾小球功能正常组(A组,Ccr≥80ml/min)和肾小球功能损害组(B组,Ccr<80ml/min)。再测定A组、B组及正常对照组血清CysC浓度UAER和血清肌酐(Scr)水平,分析以上指标单检和联检对早期肾损害阳性检出率差异。结果:A组、B组CysC、UAER和Scr水平均显著高于对照组(P<0.05)。B组高于A组(P<0.01)。A组患者血清CysC、UAER单检阳性率分别为41.84%和36.73%,二者联合检测的阳性率增至58.16%(P<0.01),B组患者血清CysC、UAER单检阳性率分别为90.54%和80.18%,二者联检的阳性率增至97.75%(P<0.01)。结论:血清Cy-sC、UAER联合检测有助于及早发现原发性高血压早期肾损害。
Objective:To investigate serum cystatin C(CysC) and UAER in patients with essential hypertension,and evaluate diagnostic value for early renal function injury in hypertension. Method:According to creatinine clearance (Ccr),320 patients with newly diagnosed hypertension were divided into two groups:normal renal function group (A group,Ccr≥80 ml/min) and impaired renal function group(B group,Ccr<80 ml/min).Serum CysC,UAER and serum creatinine (Scr) were measured in 320 patients and 120 healthy persons.Results:SysC,UAER and Scr in A group and B group were higher than control group(P<0.05),while serum CysC,UAER and Scr in A group were significantly lower than B group(P<0.01). In A group,positive rate of serum CysC was 41.84%;positive rate of UAER was 36.73%;positive rate of cystatin C+UAER was 58.16%(P<0.01). In B group,positive rate of serum CysC was 90.54%;positive rate of UAER was 80.18%;positive rate of CysC+UAER was 97.75%.Conclusion:Combinative measurement of serum cystatin C and UAER is helpful for diagnosis of early renal function injury in patients with essential hypertension.
出处
《微循环学杂志》
2011年第1期39-41,I0002,共4页
Chinese Journal of Microcirculation
