摘要
胆汁清除是药物在体内清除的主要途径之一，豚鼠灌服补骨脂水煎剂６次（１次／ｄ），从胆管取胆汁，测定胆汁中结合态和游离态的补骨脂内酯浓度之和，研究其随时间而变化的动力学过程并求出动力学参数。豚鼠灌服高剂量补骨脂水煎剂的胆汁排泄量明显高于低剂量组，提示补骨脂可能有利胆作用。
Bile elimination is one of the main routes of drug elimination from the body.After fed with Fructus Psoraleae decoction once daily for 6 days,the combined psoralen and free psoralen in the bile of guinea pigs were measured.The quantities of total psoralen were observed in different times and analyzed to calculate the pharmacokinetics parameters of psoralen elimination from the bile.The exereted bile volume in guinea pigs with higher dose of Fructus Psoraleae decoction was much more than that with lower dose,suggesting that Fructus Psoraleae may possess a cholagogic effect.
出处
《中药新药与临床药理》
CAS
CSCD
1999年第3期162-164,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家中医药管理局重点资助课题
关键词
补骨脂内酯
药代动力学
胆汁清除
Fructus Psoraleae /pharmacokinetics
@ Bile Elimination
