摘要
目的探讨晚发型情感性障碍的遗传方式。方法对６７例３０岁以后首次发病的情感性障碍家系采用分离分析和多基因阈值理论进行遗传方式的探讨。结果加权平均遗传率为５３０％±１１６％，预期发病率为１４６％，与实际发病率１２７％比较无显著性差异。结论提示晚发型情感性障碍的遗传方式为多基因遗传方式。
Objective To explore the mode of inheritance of late onset affective disorders.Method The families of 67 probands with affective disorder which begin after 30 years were studied by segregation analysis and polygenic threshold theory.Results The weighted mean of the heritability and standard error is 53.0±11.6%.The expected incidence to be 1.46%.Compared with the real incidence 1.27%,there was no significant difference.Conclusion The findings suggest that the mode of inheritance of late onset affective disorders was in conformity to multifactorial inheritance.
出处
《四川精神卫生》
1999年第3期152-154,共3页
Sichuan Mental Health
关键词
晚发型
情感性障碍
遗传方式
late-onset Affective disorder Genetic model
