摘要
目的 了解肝动脉栓塞化疗 (TACE)联合中药黄参冲剂治疗对肝癌细胞凋亡的诱导作用。方法将 4 1例原发性肝癌分成两组 :TACE组 ( 2 0例 )单纯给予TACE治疗 ;联合组 ( 2 1例 )在TACE治疗后给予中药黄参冲剂治疗。疗程结束后进行肝癌组织活检 ,用TdT介导的dUTP缺口末端标记技术检测肝癌细胞凋亡状态。采用Karnofsry评分标准评价临床症状改善情况。结果 治疗结束后TACE组和联合组肝癌细胞凋亡指数分别为 ( 3 5 3± 15 7) %和 ( 5 8 1± 2 6 4 ) %。联合组临床症状改善优于TACE组。结论 肝动脉栓塞化疗联合中药黄参冲剂治疗能增强肝癌细胞凋亡 。
Objective To study the effects of liver cancer cell apoptosis by transcatheter arterial chemoembolization (TACE) combined with the treatment of huangshenchongji for primary hepatocellular carcinoma.Methods 41 cases with primary hepatocellular carcinoma (PHC) were divided into two groups. In group A, 20 patients treated with TACE, and in group B, 21 patients were treated with TACE and huangshenchongji. Results In group A and B, the apoptosis indexes were (35 3±15 7)% and (58.1±26.4)% respectively. Conclusion Treatments of TACE combined with huangshenchongji can enhanced apoptosis on primary hepatocellular carcionma.
出处
《广东医学》
CAS
CSCD
1999年第6期407-408,共2页
Guangdong Medical Journal
关键词
细胞凋亡
肝肿瘤
栓塞疗法
中医药疗法
Apoptosis Primary hepatocellular carcinoma\ Chemoembolization Huangshenchongji
