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辅酶Q_(10)联合辛伐他汀改善慢性心力衰竭患者心功能的疗效观察 被引量:5

Observations on the effect of Coenzyme Q_(10) combined with Simvastatin on the improvement of cardiac function of chronic heart failure patients
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摘要 目的探讨辅酶Q10联合辛伐他汀对心力衰竭患者心功能的临床疗效。方法 90例慢性心力衰竭患者随机分为治疗组与对照组。对照组给予常规治疗,包括强心剂、利尿剂、扩血管剂、抗凝剂、血管紧张素酶抑制剂、β受体阻滞剂等。治疗组在常规治疗的基础上给予辅酶Q1030 mg,3次/d;辛伐他汀20 mg,睡前服用,疗程为8周。所有患者于治疗前检查心功能测定包括射血分数、左室舒张末内径、6 min步行距离,治疗后2个月复查上述指标。随访12个月。结果两组治疗后在心功能改善方面,治疗组与对照组比较有显著性差异;随访12个月,治疗组在住院天数和住院次数方面与对照组相比有明显差异。结论辅酶Q10联合辛伐他汀对改善慢性心力衰竭患者心功能的临床疗效明显,安全可靠,值得临床推广应用。
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2011年第1期56-59,共4页 Chinese Journal of Biochemical Pharmaceutics
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参考文献13

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