摘要
目的观察他汀类降脂药辛伐他汀对冠心病慢性心力衰竭预后的影响.方法2001-12～2003-12广东省潮州市中心医院,冠心病慢性心力衰竭患者114例,随机分成辛伐他汀组(59例),对照组(55例).所有心力衰竭患者均常规治疗,治疗组加用辛伐他汀20 mg,每晚1次.治疗2个月后复查血脂常规、C反应蛋白(C-RP)、左室射血分数(LVEF).观察所有患者的住院次数、总日数、病死率.结果辛伐他汀治疗组及对照组比较,治疗2个月后,血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、C-RP均有不同程度的降低,LVEF则有明显提高.治疗组和对照组比,住院次数和总日数减少,但差异无显著性(P＞0.05);病死率明显降低,两组相比差异有非常显著性(P＜0.01).结论辛伐他汀治疗冠心病慢性心力衰竭能够改善患者的预后.
Objective To observe the effects of simvastatin o n the prognosis of patients with chronic heart failure with coronary heart diseas e.Methods During 2001-12~2003-12,114 cases were divided randomly into two groups:the treatment group(n=59),who received simvastatin 20mg QN,a nd the control group(n=55) .All patients with heart failure were treated by conventional therapy.Results Compared with the control group,the total cholesterol ( TC),LDL-C,C-RP of the patients in the treatment group were all degraded to dif ferent degrees and the LVEF was elevated obviously.The frequency of hospitaliza tion and the time were lower than that in the control group but were not signifi cantly different;the death rate was significantly lower than that in the control group(P<0.01).Conclusion The prognosis of patients with chronic heart failure with coronary heart disease can be improved by simvastatin.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第4期338-339,共2页
Chinese Journal of Practical Internal Medicine
