摘要
本研究使用具有不同交联度(CLD)的β-环糊精聚合物(β-CDP)为载体与布洛芬形成包合物,考察β-CDP结构和组成对药物载入和释放的影响。通过FT-IR和13C NMR确定β-CDP结构特征。结果表明在β-CDP中仍保留β-CD的原有结构特征。β-CDP的CLD是决定药物载入及释放的重要因素,增加β-CDP的CLD会使药物的载入量减少,释放量增大。
The purpose of the present study is to use β-cyclodextrin polymers（β-CDP） with different cross-linked degree（CLD） to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of β-CDP on its drug loading and release behaviors.A series of β-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy（FT-IR） and 13C NMR spectrum.The β-CDP was systemically characterized for the relation between the CLD of β-CDP and the drug loading and release as well.The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of β-CDP and β-CD implies that the polymer keeps the original characteristic structure of β-CD.The CLD of the β-CDP played a critical role in the drug loading and release,increasing the CLD resulted in reduction of drug loading,but increase in drug release.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第2期221-226,共6页
Acta Pharmaceutica Sinica
