摘要
目的观察羟乙基淀粉130/0.4氯化钠注射液(商品名:亿汶)在重症急性胰腺炎(SAP)患者中应用的有效性及安全性。方法 48例未手术的SAP患者,用随机方法分成治疗组和对照组,各24例。两组均禁食、胃肠减压、抑酸、抑酶、抑制胰腺分泌、抗炎、维持水盐电解质平衡及营养支持治疗,治疗组羟乙基淀粉130/0.4,500 m l/d,静脉滴注疗程7 d;对照组乳酸钠林格氏液500 m l/d,静脉滴注疗程7 d。观察两组血液流变学、凝血功能的变化。结果治疗7 d后,治疗组血液流变学及凝血功能改善程度好于对照组,差异有统计学意义(P<0.05)。结论羟乙基淀粉130/0.4可能通过改善微循环从而促进重症急性胰腺炎的转归。
Objective To observe the efficacy and safety of hydroxyethyl starch 130/0.4 in severe acute pancreatitis（SAP） patients.Methods 48 SAP patients（without surgical operation） were randomized into treatment group and control group,24 cases respectively.Both groups were conducted to fasting,gastrointestinal decompression,suppression of acid and enzyme,pancreatic secretion,anti-inflammatory,maintain water quality in the salt solution balance and nutrition support.Hydroxyethyl starch 130/0.4 was used in treatment group,500ml/d intravenous drip,7 days as a therapy circle;sodium Lactated Ringer′s solution was used in control group,500ml/d intravenous drip,7 days as a therapy circle.Then observe the change of blood rheology,coagulation function.Results After 7 days of treatment,the changes of blood rheology and blood coagulation function were different significantly（P〈0.05）,the improvement of the treatment group are better than control group.Conclusion It′s likely that hydroxyethyl starch 130/0.4 can improve microcirculation so as to improve the outcome of severe acute pancreatitis.
出处
《内科》
2010年第6期575-577,共3页
Internal Medicine
关键词
羟乙基淀粉
重症急性胰腺炎
血液流变学
凝血功能
Hydroxyethyl starch
Severe acute pancreatitis
Hemorheology
Blood coagulation function
