摘要
目的用中药心脉通1号(瓜蒌通脉丸)对冠状动脉内支架血栓、支架内再狭窄(RS)的作用进行研究。方法将100例冠心病支架置入成功的患者,随机分为支架术常规用药组(对照组)50例,心脉通1号联合组(治疗组)50例,应用全血流式细胞术检测血小板膜糖蛋白中活化的GPⅡb/Ⅲa(PAC—1)、P-选择素(CD62P)以及用荧光散射比浊法测血浆纤维蛋白原(Fg),采用免疫透射浊度法测血浆高敏C反应蛋白(hs-CRP)的变化。观察比较支架术后冠脉事件发生情况及中医证候的变化。结果两组术前PAC—1、CD62P、Fg及CRP水平,差异无显著性(P>0.05),两组术后与术前比较,以上指标均有明显上升,差异有显著性(P<0.01),术后30d两组以上指标较本组术后均有明显下降,差异有显著性(P<0.01),术后30d时中药组CRP下降较常规组明显,差异有显著性(P<0.05)。结论心脉通1号联合治疗在降低支架内再狭窄的发生方面优于阿司匹林和氯吡格雷,可能心脉通1号具有抑制血小板活化、抑制炎症反应的作用。
Objective To study the effects of Xinmaitong No.1（Gua Lou Tong Mai Pill） on the coronary thrombus and arterial restenosis after stent implantation. Methods 100 patients successfully implanted with intracoronary stents were divided into two groups,one（control group,50 cases） treated with conventional prescription and the other（treatment group,50 cases） treated in combination with Xinmaitong No.1.The activated GPⅡb/Ⅲa（PAC—1） and P-selectin（CD62P） were detected by flow cytometry,plasma fibrinogen was detected by fluorescent scattering,and CRP was detected by biuret method. Results Preoperative levels of PAC—1、CD62P、Fg and CRP between the two groups were of no significant difference（P0.05）.Such levels upgraded significantly after the operation（P0.01） and showed a significant degradation after 30 days among the same group（P0.01）.CRP of the treatment group degraded more significantly than that of the control group（P0.05）.Conclusion Combined treatment with Xinmaitong No.1 has an advantage over acenterine and Ticlopidine.Xinmaitong No.1 may help to retrain thrombocyte activation and inflammatory reaction.
出处
《医学研究与教育》
CAS
2010年第6期56-60,63,共6页
Medical Research and Education
基金
河北省科技研究与发展计划项目(04276191)
关键词
冠状动脉狭窄/中医药治疗
介入治疗后/药物作用
心脉通1号
coronary stenosis/treatment by TCM
interventional therapy/drug action
Xinmaitong No.1（Gua Lou Tong Mai Pill）
