摘要
目的观察中药复方制剂肝复乐胶囊治疗慢性乙型肝炎、肝硬化患者的疗效。方法慢性乙型肝炎、肝硬化患者102例,分为3组:对照组A(34例)采用常规保肝治疗加安慰剂胶囊,对照组B(34例)采用常规保肝治疗加肝友胶囊,治疗组(34例)采用常规保肝治疗加肝复乐胶囊,疗程均为8周。治疗前后测定血清中透明质酸(HA)、IV型胶原(CIV)、层粘连蛋白(LN)。结果治疗组用药后HA为(87.3±36.6)μg.L-1,CIV为(5.2±0.7)μg.mL-1,LN为(373.2±49.6)μg.L-1,与对照组A比有显著性差异(P<0.05)。肝功能复常情况治疗组ALT为(35.9±3.3)U.L-1,AST为(35.8±5.4)U.L-1,Tbil为(16.6±4.2)μmol.L-1;治疗组第8周后的主要症状改善率(100.0%)显著高于对照组A(82.4%)(P<0.05),略高于对照组B(91.2%)(P>0.05)。结论肝复乐胶囊具有减轻肝细胞炎症及抗肝纤维化的作用,可以作为慢性乙型肝炎、肝硬化综合治疗用药选择。
Objective To observe the efficacy of Ganfule Jiaonang,a Chinese traditional medicine compound preparation,for chronic hepatitis B and cirrhosis treatment.Methods A total of 102 patients who had chronic hepatitis B and cirrhosis were divided into 3 groups.Patients（n=34） in the control group A were given routine medical therapy and placebo Jiaonang;patients（n=34） in the control group B were given routine medical therapy and Ganyou capsules（another Chinese traditional medicine compound preparation）;and patients（n=34） in the treatment group were given routine medical therapy and Ganfule Jiaonang.The usage for Ganfule Jiaonang was 6 pellets at a time,3 times a day for 8 weeks.Some serum indicators for hepatic functions such as alanine aminotrabsferease（ALT）,hyaluronic（HA）,collagen type IV（CIV） and lamini（LN） were tested before and after the treatment.Results In the treatment group,the serum HA concentration was（87.3 ±36.6） μg·L-1,the serum CIV concentration was（5.2 ±0.7）μg·mL-1,and the serum LN concentration was（373.2±49.6）μg·L-1 after the therapy（compared with the control group A and B,all P values〈0.05）.In the control group A and B,no changes were observed for HA,CIV and LN before and after the therapy（all P values〈0.05）.With normal liver function,the serum ALT,AST and Tbil concentrations were（35.9±3.3）U·L-1,（35.8±5.4）,and（16.6±4.2） μmol·L-1.Eight weeks after the treatment,the rate of recovery in the treatment group was 100.0%,compared with the control group A（82.4%,P〈0.05）and the control group B（91.2%,P〉0.05）.Conclusion Ganfule Jiaonang can alleviate liver inflammation and resist liver fibrosis,indicating that it is effective for chronic hepatitis B and cirrhosis treatment.
出处
《中南药学》
CAS
2010年第11期872-875,共4页
Central South Pharmacy
关键词
肝复乐胶囊
乙型肝炎
肝硬化
临床疗效
Ganfule Jiaonang
hepatitis B
cirrhosis
clinical efficacy
