摘要
目的:探讨复方甘草酸苷治疗慢性乙型肝炎肝纤维化的临床疗效。方法:150例患者随机分为2组各75例,对照组进行常规保肝治疗,治疗组加用复方甘草酸苷,4周为一疗程。测定治疗前后的肝功能及肝纤维化指标。结果:治疗组和对照组总有效率分别为93.3%和84.0%,组间比较差异有显著性(P<0.05);治疗后2组患者肝功能及肝纤维化指标均有一定程度改善,其中治疗组肝功能ALT、AST、GGT、TBIL及肝纤维化指标HA、LN、PCⅢ、IVC、TGF-β1的改善程度均优于对照组(P<0.05或P<0.01)。结论:复方甘草酸苷可明显改善慢性乙型肝炎患者肝功能、减轻肝纤维化,值得临床推广应用。
OBJECTIVE To evaluate the efficacy of compound glycyrrhizin on hepatic fibrosis of chronic hepatitis B. METHODS 150 patients were randomly divided into 2 groups： 75 cases of the control group were treated with conventional liver protection; 75 cases of the study group were treated with compound glycyrrhizin, additionally. All treated for 4 weeks. The hepatic function and hepatic fibrosis index before and after treatment, the clinical effects were observed. RESULIS The clinical efficiency was 93.3% in study gronp and 84. 0% in control group, the difference between two groups was statistically significant （P〈0. 05）. After treatment, the hepatic function and hepatic fibrosis index of all patients were improved to some extent; ALT, AST, GGT, TBIL of hepatic function and HA, LN, PCⅢ, IVC, TGF-β1 of hepatic fibrosis index were all decreased significantly in the study group compared with the control group （P〈0. 05 or P〈0.01 ）. CONCLUSION The improvement of hepatic function and the alleviation of fibrosis after combining treatment with compound glycyrrhizin is significant, it is worthy of wide clinical use in the treatment of chronic hepatitis B.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第14期1213-1215,共3页
Chinese Journal of Hospital Pharmacy
关键词
复方甘草酸苷
慢性乙型肝炎
肝纤维化
肝功能
肝纤维化指标
临床观察
compound glycyrrhizin
chronic hepatitis B
hepatic fibrosis
hepatic function
hepatic fibrosis index
clinical observation
