摘要
目的观察黄连与吴茱萸不同配伍比例(黄连-吴茱萸分别为6∶1、2∶1、1∶1、1∶6)在热环境下对大鼠肛温、生存时间和死亡率的影响,确定其对增强大鼠热耐受能力的差异。方法将SD大鼠随机分为6组,空白对照组(A组)给生理盐水,阳性对照组(B组)给藿香正气水,实验组(C、D、E、F组)分别给黄连、吴茱萸药对各配伍比例提取物。6组同时放入温度为41℃,相对湿度为70%的人工热室中受热至死。热暴露前测各鼠肛温1次,热暴露1 h后再测1次肛温,并记录各鼠死亡时间。结果 B组和C、D、E、F组均能不同程度降低大鼠肛温、死亡率,延长存活时间,其中以D组效果最为显著。结论黄连-吴茱萸2∶1能显著增强大鼠热环境的耐受能力,抗中暑作用最为明显。
Objective To observe the effect of compatibility in Coptis chinensis Franch and Evodia rutaecarpa （Juss） Benth （6 ： 1, 2 ： 1, 1 ： 1, 1 ： 6） on anus temperature, survival time, and mortality in thermal environment in rats and the difference in enhancing the heat tolerance. Methods SD rats were randomly divided into 6 groups： the blank group was treated with saline water, the positive control group with the agastache rugosaq healthy water, while the experimental group C, D, E, and F with various compatibility proportions of extracts in Coptis chinensis Franch and Evodia rutaecarpa （Juss） Benth. Then the rats were exposed to heat at 41 ℃ in a heat chamber with relative humidity of 70% till death. The rectal temperature was measured before and 1 h after the heat exposure, and the time when death occurred were recorded. Results Compared with the blank group, group B, C, D, E and F had lower rectal temperature and prolonged survival time with decreased mortality. Group D had better action than the others. Conclusion Coptis chinensis Franch and Evodia rutaecarpa （Juss） Benth （2 ： 1） can significantly enhance the thermal environment of tolerance, which has the most obvious heat resistant function.
出处
《中南药学》
CAS
2010年第11期830-832,共3页
Central South Pharmacy
关键词
黄连吴茱萸药对
热环境
肛温
热耐受
compatibility of Coptis chinensis Franch and Evodia rutaecarpa （Juss） Benth
thermal environment
anus temperature
heat tolerance
