摘要
目的观察吡格列酮对糖尿病肾病（DN）患者血清炎性因子的影响。方法60例DN患者随机分为对照组和治疗组。治疗12周，治疗前及治疗12周时取外周静脉血及24h尿，采用放射免疫法测IL-6、IL-18、TNF-α．水平和尿白蛋白含量。CRP测定采用免疫比浊法。结果与治疗前比较，两组患者尿蛋白均有所下降（P〈0．05），治疗组较对照组下降更明显（P〈0．01）。经吡格列酮治疗12周后，血清IL-6、IL-18、TNF-α和CRP，与治疗前比较有显著下降，差异有统计学意义（P〈0．05）。结论吡格列酮能降低DN患者血清炎症因子水平，减少尿蛋白排泄，具有抗炎、保护肾脏作用。
Objective To investigate the effect of pioglitazone on inflammatory factor in patients with diabetic nephmpathy. Methods Sixty patients with diabetic nephmpathy were randomly divided into contol group and therapeutic group, therapeutic group treated with pioglitazone for 12 weeks. Their venous blood and 24 hour urine samples were collected before and after treatment for determination of inflammatory factor and urine protein by radioimmunity. C reatvie protein was detected by immunoturbidimetry. Results The amount of urine protein in DN patients after treatment were lower than those of before treatment（ P 〈 0.05 ）. The serum level of inflammatory factor in DN patients after treated with pioglitazone were lower than those of before treatment （ P 〈 0.05 ）. Conclusion Pioglitazone can decrease the serum level of inflammatory factor, and amount of urine protein, which can anti inflammatory and protect the kidney function.
出处
《中外医学研究》
2010年第30期13-15,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
吡格列酮
糖尿病肾病
炎症因子
Pioglitazone
Diabetic nephrepathy
Inflammatory factor
