期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

病毒miRNA的研究进展 被引量：3

原文传递
导出
摘要 MicroRNA(miRNA)是指一组由多细胞生物产生的小片段非编码RNA,是真核生物基因调控重要的组成成分。近些年来有研究者在病毒中也同样发现编码产生的miRNA,其可通过RNA干扰途径参与调节感染过程以及促进癌症的发生。因此阻止病毒小RNA生成有望成为治疗病毒相关疾病的新方法。
作者 刘春亮 唐立
机构地区 大连医科大学微生态学教研室
出处 《中国微生态学杂志》 CAS CSCD 2011年第1期84-85,88,共3页 Chinese Journal of Microecology
基金 国家自然基金(30670045) 国家"973"科学计划项目(2007CB513006) 国家"863"科学计划项目(2007A10Z356)
关键词 MIRNA 病毒miRNA RNA干扰
分类号 R373 [医药卫生—病原生物学]
  • 相关文献

参考文献30

  • 1AMBROS V, BARTEL B, BARTEL D P,et al. A uniform system for microRNA annotation[ J]. RNA ,2003,9 (3) :277-279.
  • 2BARTEL D P. MicroRNAs: genomics, biogenesis, mechanism, and function[ J]. Cell,2004,116(2) :281-297.
  • 3CULLEN B R. Transcription and processing of human microRNA precursors[J]. Mol Cell,2004,16(6) :861-865.
  • 4CARRINGTON J C ,AMBORS V. Role of microRNAs in plant and animal development [ J ]. Science,2003,301 (5631) :336-338.
  • 5PFEFFER S,ZAVOLAN M, GRASSER F A, et al. Identification of vires-encoded microRNAs [ J]. Science,2004,304 (5671) :734-736.
  • 6NAIR V,ZAVOLAN M. Virus-enceded microRNAs: novel regulators of gene expression [ J ]. Trends Microbiol,2006,14 (4) : 169-175.
  • 7SULLIVAN C S,GRUNDHOFF A T,TEVETHIA S,et al. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells [ J ]. Nature, 2005,435 ( 7024 ) : 682-686.
  • 8KIM DO N,CHAE H S. Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma[ J]. J Virol, 2007,81 (2) : 1033- 1036.
  • 9REINHART B J,SLACK F J,BASSON M,et at. The 21 nucleotide let- 7 RNA regulates developmental timing in Caenorhab-ditis elegans[J]. Nature,2000,403(6772) :901-906.
  • 10SLACK F J,BASSON M,LIU Z,et al. The lin-41 RBCC gene acts in the C. elegans heteroehronie pathway between the let-7 regulatory RNA and the LIN-29 transeription factor [ J ]. Mol Cell, 2000,5 ( 4 ) : 659- 669.

同被引文献49

  • 1Croce CM. Causes and consequences of miRNA dysregulation in cancer[J]. Nat Rev Genet, 2009,10 : 704-714.
  • 2Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles clas- sify human cancers[J]. Nature,2005,435(7043) :834-838.
  • 3Mitchell PS,Parkin RK, Kroh EM, et al. Circulating microRNAs stable blood based markers for cancer detection[J].Proc Natl Acad Sci USA,2008,105(30):10513-10518.
  • 4Iorio MV,Casalini P,Piovan C,et al. miRNA-205 regulates HER3 in human breast cancer[J]. Cancer Res,2009,69(6) :2195-2200.
  • 5Shimono Y,Zabala M,Cho RW,et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells[J]. Cell, 2009,138 (3) : 592-603.
  • 6Shi L,Zhang J,Pan T,et al. MiR-125b is critical for the suppres- sion of human U251 glioma stem cell proliferation[J]. Brain Res, 2010,1312 : 120-126.
  • 7Ji Q,Hao X,Zhang M,et al. MiRNA miR-34 inhibits human pan- creatic cancer tumor-initiating cells [J]. PLoS One, 2009, 4 (8) : e6816.
  • 8Wang Z, Li Y, Ahmad A, et al. Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in o vercoming drug resistance[J]. Drug Resist Updat, 2010,13(4/5) : 109-118.
  • 9Gregory PA, Bert AG, Paterson El., et al. The miR 200 family and miR-205 regulate epithelial to mesenehymal transition by tar- geting ZEB1 and SIPI[J]. Nat Cell Biol,2008,10(5) :593-601.
  • 10Li Y, Vandenboom TG, Kong D, et al. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to- mesenchymal transition in gemcitabine-resistant pancreatic cancer cells[J]. Cancer Res, 2009,69 (16) : 6704-6712.

引证文献3

二级引证文献11

中国微生态学杂志
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部