摘要
目的评价清热化痰方药对慢性阻塞性肺疾病急性加重期(AECOPD)痰热壅肺证患者的临床疗效。方法选取AECOPD患者140例,随机分为试验组和对照组,两组均参照《慢性阻塞性肺疾病诊治指南》的急性加重治疗方案实施,试验组在以上治疗的基础上,给予清热化痰方药,对照组给予安慰剂。7天为1个疗程,共观察2个疗程。观察患者临床综合疗效、单个症状疗效、实验室指标及生存质量。结果两组患者共脱落6例,试验组69例,总显效57例占82.6%;对照组65例,总显效34例占52.4%,临床综合疗效比较差异有统计学意义(P<0.05)。在咳嗽、咯痰、胸闷、喘息、食欲不振5个症状方面试验组疗效优于对照组(P<0.05)。试验组可改善患者的肺功能、促进炎症的吸收、提高生存质量(P<0.05或P<0.01)。结论清热化痰方药治疗AECOPD痰热壅肺证患者临床疗效确切,可明显改善临床症状和肺功能,提高生存质量。
Objective To evaluate comprehensively the effect of Qingre Huatan Formula （formula for heat-clearing and phlegm-dissolving） on the phlegm heat in lung of acute embittering chronic obstructive pulmonary disease （AECOPD）. Methods Totally 140 AECOPD patients were randomized into test group and control group,both were treated according to the Guide on Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease,additionally,the test group was administered heat-clearing and phlegm-dissolving formulas,while the control group was given placebo,7 days as one course of treatment,totally for 2 courses. The comprehensive effect,single symptom effect,lab indices,and survival quality were observed. Results The dropout of two groups was 6 cases in all. Of the 69 cases in the test group,57 （82.6%） were remarkably effective; of the 65 cases in the control group,34 （52.4%） were remarkably effective. There was statistical difference in the comprehensive effect between （P〈0.05）. In improving the symptoms including cough,expectoration,fullness in chest,asthmatic breathing,and poor appetite,the effect of the test group was better than that of the control group （P〈0.05）. In the test group,there existed an improvement of lung function,promotion of absorption of inflammation,and promotion of survival quality （P〈0.05 or P〈0.01）. Conclusion Qingre Huatan Formula is effective in treating AECOPD,significantly improving the clinical symptoms and lung function in enhancing the survival quality.
出处
《中医杂志》
CSCD
北大核心
2011年第3期203-207,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助(30772797)
关键词
清热化痰方
慢性阻塞性肺疾病
急性加重期
痰热壅肺证
临床疗效
Qingre Huatan Formula （formula for heat-clearing and phlegm-dissolving）
chronic obstructive pulmonary disease
acute embittering stage
phlegm heat in lung
clinical effect
