摘要
目的：研究乳腺癌术前化疗的临床意义。方法：用 Ｃ Ｍ Ｆ 方案术前诱导化疗治疗Ⅲ期乳腺癌７６例（ 实验组） 。同期１０７ 例乳腺癌未行术前化疗（ 对照组） 。结果：实验组和对照组５ 年生存率分别是５１３ ％ 和４６７ ％ （ Ｐ＞ ００５） ，１０ 年生存率分别是３０７ ％ 和２５８ ％ （ Ｐ＜ ００５） 。实验组中４９ 例术前化疗之后原发灶肿瘤直径缩小＞ ２０ ％ （ 敏感组） 。２７ 例肿瘤缩小＜ ２０ ％ （ 非敏感组） 。敏感组和非敏感组５年生存率分别是６１２ ％ 和３３３ ％ （ Ｐ＜ ００１） 。结论：术前诱导化疗对提高Ⅲ期乳腺癌的长期生存有重要意义。通过术前观察肿瘤对诱导化疗方案的敏感情况，可指导术后辅助化疗方案的选择，进一步提高治愈率。
Objective:To study the clinical significance of preoperative induced chemotherapy of stage Ⅲ breast cancer treated.Methods:76 cases of stage Ⅲ breast cancer were treated by preoperative induced chemotherapy with CMP rigmen,while control group was 107 cases.Results: The 5 year and 10 year surival rates of treatment group were 51 3% and 30 7% respectively,these were significant better than those of the control group.The primary tumor reduced more than one fifth in size in 49 cases of group A,but reduced less than one fifth in the other 27 cases of group B.The 5 year survival rates of group A and B were 61 2% and 33 3% respectively( P <0 01).Conclusions:The preoperative induced chemotherapy is important for prolonging the survival of stage Ⅲ breast cancer.It can guide the adjuvant chemotherapy after operation for stage Ⅲ brcast cancor.
关键词
乳腺癌
预后
术前
药物疗法
preoperative induced chemotherapy
stage Ⅲ breast cancer
prognosis
