摘要
近年来,趋化因子在肿瘤生长和转移中的作用引起人们的强烈关注。在多种肿瘤中(包括乳腺癌、胰腺癌、前列腺癌、结直肠癌等)发现,CXCL12/CXCR4分子对能够促进肿瘤细胞的生长,抑制肿瘤细胞的凋亡,促进肿瘤血管生成,影响某些肿瘤的靶向转移,增强肿瘤细胞的黏附和迁移能力,影响肿瘤细胞的分泌行为,提示该轴可能成为抗肿瘤药物的新靶点,具有潜在的临床应用前景。
In recent years,the role of chemokines in tumor growth and metastasis have been attracting greater attention worldwide.Studies on breast cancer,prostate cancer and pancreatic cancer have revealed that CXCL12/CXCR4 axis can increase the growth,inhibit the apoptosis,promote the angiogenesis,affect the targeted metastasis,enhance the adhesion and migration,and regulate the cytokine secretion of tumor cells,which indicates CXCL12/CXCR4 axis may be a new target for antitumor drugs and plays a potential role in clinical tumor therapy.
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
北大核心
2010年第6期683-686,共4页
Chinese Journal of Cancer Biotherapy
基金
国家自然科学基金资助项目(No.30872303)~~
