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MicroRNA与肝病及肝纤维化相关研究 被引量：6

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摘要 MicroRNA（miRNA）是转录后水平的细胞调控因子。在细胞核内，miRNA基因经由RNA聚合酶Ⅱ介导转录出含多聚腺苷酸尾（A从从）和帽子结构特征性标志的州一miRNA，后者在核酸酶Drosha的作用下被切割成70个具有茎环结构的miRNA前体（pro—miRNA），随后由转运蛋白exportin-5转运出核，再由胞质中Dicer蛋白切割为成熟的miRNA。
作者 许蜜蝶 李维卿 余宏宇
机构地区 第二军医大学附属长征医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2011年第1期65-67,共3页 Chinese Journal of Pathology
关键词 MICRORNA 肝纤维化 miRNA RNA聚合酶Ⅱ 肝病 细胞调控因子 转运蛋白 RNA基因
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献23

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二级参考文献14

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共引文献6

同被引文献67

  • 1陆伦根,曾民德.肝纤维化的诊断和评估[J].中华肝脏病杂志,2005,13(8):603-604. 被引量：100
  • 2孙凯,汪谦.液相芯片技术在小分子RNA检测分析中的应用[J].中华医学杂志,2006,86(20):1437-1439. 被引量：14
  • 3刘厚森,唐胜球,董小英,邹晓庭.极低密度脂蛋白受体的研究[J].安徽农业科学,2006,34(13):2984-2987. 被引量：3
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  • 8Pogribny IP,Starlard-Davenport A,Tryndyak VP. Difference in expression of hepatic microRNAs miR-29c,miR-34a,miR-155,and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice[J].{H}Laboratory Investigation,2010,(10):1437-1446.
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引证文献6

二级引证文献33

中华病理学杂志
2011年 第1期

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