摘要
目的 观察体质指数正常、腹部内脏脂肪沉积的非代谢综合征老年男性患者血清脂联素、瘦素水平及脂联素瘦素比值的变化.方法 将入选的老年非代谢综合征男性患者109例分为2组,内脏无脂肪沉积组67例,内脏脂肪沉积组42例.采用CT方法测定内脏脂肪面积,当腹部内脏脂肪面积≥100cm2,为内脏脂肪沉积;采用LINCO公司提供的放射免疫试剂盒测定空腹血脂联素、瘦素水平;代谢综合征的诊断采用2004年中国糖尿病学会制定的标准.结果 （1）脂肪沉积组与无脂肪沉积组比较,体质指数、内脏脂肪面积均显著升高,体质指数分别为（22.94±1.35）kg/m2对（21.38±2.55）kg/m2（P＜O.001）,内脏脂肪面积（135.6±31.7）cm2对（68.6±22.6）cm2（P＜O.001）;脂联素瘦素比值降低.分别为2.17±1.77对4.54±7.00（P=0.031）;而脂联素、瘦素水平在两者间差异无统计学意义;（2）脂联素瘦素比值与体质指数（r=-0.552,P＜0.001）、腰围（r=-0.390,P＜0.001）、腹部内脏脂肪面积（r=-0.311,P＜0.001）呈负相关.结论 体质指数正常有内脏脂肪沉积与无内脏脂肪沉积的老年男性比较.脂联素瘦素比值明显下降.并与腹部脂肪面积显著负相关.提示血清脂联素瘦素比值可能可用于筛选体质指数正常有腹部内脏脂肪肪沉积的患者.
Objective To observe the serum adiponectin, leptin level, and adiponectin/leptin ratio （A/L ratio） in elderly male patients with normal BMI and visceral adipose deposit but without metabolic syndrome. Methods A total of 109 elderly males （≥60 years old） were enrolled whose BMI were all less than 25 kg m and without metabolic syndrome. They were divided into non visceral adipose deposit group （n = 67） and visceral adipose deposit group （n = 42 ）. Serum levels of adiponectin and leptin were measured by radiological immunological assay （RIA） and the A/L ratio was calculated. Visceral adipose deposit was defined as visceral adipose area more than 100 cm2.Metabolic syndrome diagnosis was according to the definition provided by China Diabetes Society （CDS） in 2004. Results （1）The visceral adipose area [（135.56±31.72）cm2 vs. （68. 65±22.64）cm2 , P〈 0. 001] and BMI [（22.94 ± 1.35 ） kg/m2 vs. （ 21.38 ± 2.55 ） kg/m2 , P 〈 0.001] were significantly higher in visceral adipose deposit group than in non visceral adipose deposit group. The A/L ratio was significantly lower in visceral adipose deposit group than in non visceral adipose deposit group （ 2. 17 ± 1.77 vs. 4.54 ± 7.00, P = 0. 034 ） while there was no difference in serum adiponectin or leptin level between those two groups. （2）The A/L ratio was negatively correlated with BMI （r=-0.552, P〈0.001）, waist circumstances （r=-0.390, P〈0.001） and abdominal visceral fat area （r=-0.341, P〈0. 001 ）. Conclusions The A/L ratio decreases in elderly men with normal BMI and visceral adipose deposit. A/L ratio could be useful in scanning those patients with visceral adipose deposit whose BMI is normal among elderly men.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2010年第12期977-979,共3页
Chinese Journal of Geriatrics
基金
基金项目：上海市科委资助（034119816）
关键词
脂联素
瘦索
腹部脂肪
Adiponectin
Leptin
Abdominal fat
